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196440

巴马司他

≥98% (HPLC), solid, Matrix metalloproteinase inhibitor, Calbiochem

别名:

巴马司他, （4-N-羟氨基）-2R-异丁基-3S-（噻吩硫基甲基）琥珀酰）-L-苯丙氨酸-N-甲酰胺，BB-94

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关于此项目

经验公式（希尔记法）:
C23H31N3O4S2
化学文摘社编号:
130370-60-4
分子量:
477.64
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00866533
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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产品名称

巴马司他, Batimastat primarily used in Inhibition.

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[s]1c(ccc1)SC[C@@H]([C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC)C(=O)NO

InChI

1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)/t17-,18+,19+/m1/s1

InChI key

XFILPEOLDIKJHX-QYZOEREBSA-N

General description

一种基于Marimastat（目录编号444289）的基于肽基异羟肟酸酯的抑制剂，可有效抑制广谱金属蛋白酶，包括MMP-1，MMP-2，MMP-3/溶血素，MMP-7/基质溶素，MMP-9，ΔMT1（没有TM结构域的MMP-14），ADAM8和ADAM17/TACE（IC50分别为3、4、20、6、4、2.08、51.3和19 nM），靶向底物结合位点和活性位点Zn2+，而对ACE（血管紧张素转换酶）或α-分泌酶的效力低得多（IC50分别为1.6和3.3 µM）。Batimastat被广泛用于研究MMPs在体外培养和动物体内的癌变和非癌病理过程中的参与。也可以作为25 mM的DMSO溶液（目录号508408）提供。

Packaging

用惰性气体包装

Preparation Note

复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存6个月。

Other Notes

Schlomann, U., et al. 2002.J. Biol. Chem.277, 48210.
Whittaker, M., et al. 1999.Chem. Rev.99, 2735.
Parvathy, S., et al. 1998.Biochemistry37, 1680.
Parvathy, S., et al. 1998.FEBS Lett.431, 63.
Yamamoto, M., et al. 1998.J. Med. Chem.41, 1209.
Moss, M.L., et al. 1997.Nature385, 733.
Eccles, S.A., et al. 1996.Cancer Res.56, 2815.
Brown, P.D.1995.Advan.Enzyme Regul.35, 293.
Wang, X., et al. 1994.Cancer Res.54, 4726.
Davies, B., et al. 1993.Cancer Res.53, 2087.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：标准处理（A）

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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全球贸易项目编号

货号GTIN
196440-5MG04055977206500