197228
BCRP Inhibitor IV, YHO-13351
The BCRP Inhibitor IV, YHO-13351 controls the biological activity of BCRP.
别名:
BCRP Inhibitor IV, YHO-13351, Diethylaminoacetic acid, 1-(5-(( Z)-2-cyano-2-(3,4-dimethoxyphenyl)vinyl)thiophen-2-yl)piperidin-4-yl ester, Methanesulfonate, Diethylaminoacetic acid, 1-(5-((Z)-2-cyano-2-(3,4-dimethoxyphenyl)vinyl)thiophen-2-yl)piperidin-4-yl ester, Methanesulfonate
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C26H33N3O4S · xCH4O3S
分子量:
483.62 (free base basis)
UNSPSC Code:
12352200
SMILES string
O=C(CN(CC)CC)OC(CC1)CCN1C(S2)=CC=C2/C=C(C(C=C3)=CC(OC)=C3OC)\C#N.[xCH3SO3H]
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
yellow
solubility
water: 25 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
An in vivo bioavailable (~87%; t1/2<5 mins. during p.o. and i.v. administration) and highly water soluble (>100 mg/ml) diethylaminoacetate prodrug of YHO-13177 (Cat. No. 197227) that reverses BCRP-mediated irinotecan resistance in P388/BCRP and HCT116/BCRP xenograft mouse models, and suppresses tumor growth and significantly enhances the survival (100 or 200 mg/kg, i.p.).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Yamazaki, R., et al. 2011. Mol. Cancer Ther.10, 1252.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持