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Merck
CN

197345

79-6

≥95% (HPLC), BCL6 inhibitor, powder

别名:

BCL6抑制剂,79-6

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关于此项目

经验公式(希尔记法):
C15H9BrN2O6S2
分子量:
457.28
UNSPSC Code:
12352200
NACRES:
NA.28
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产品名称

BCL6抑制剂,79-6, The BCL6 Inhibitor, 79-6 controls the biological activity of BCL6. This small molecule/inhibitor is primarily used for Cancer applications.

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

dark red

solubility

DMSO: 50 mg/mL

shipped in

ambient

Quality Level

General description

一种细胞可渗透的羟吲哚化合物,可选择性抑制BCL6的转录抑制活性(在基于293T的报告基因分析中,在50 µM时抑制约70%),但不是其他三个BTB/POZ(bric-a-brac tramtrack broad Complex/痘病毒锌指)家族成员Kaiso,HIC1和PLZF,通过BTB结构域直接BCL6结合(Kd = 138 µM)并阻断辅阻遏物BBD-(BCL6结合域)介导BCL6相互作用(IC50 = 212 µM & Ki = 147 µM,与SMRT-BBD肽竞争性结合),导致BCL依赖性DLBCL(弥漫性大B细胞淋巴瘤)中BCL6靶基因上调,但不依赖BCL的Toledo和OCI-Ly4细胞系。在体外显示出对DLBCL细胞系(IC50为24至936 µM)以及原代人DLBCL细胞的抗增殖活性,并在体内抑制小鼠中BCL依赖性肿瘤的生长(第9天为对照肿瘤大小的<40%;50 mg/kg/天,通过i.p.)。

Packaging

用惰性气体包装

Preparation Note

复溶后,等分并冷冻保存(-20°C)。储备液在-20°C条件下可稳定保存3个月。

Other Notes

Cerchietti, L.C., et al. 2010.Cancer Cell17, 400.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性:标准处理(A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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