200484-M
Bestatin
Binds to cell surfaces and inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase.
别名:
Bestatin, [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-Leu
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关于此项目
经验公式（希尔记法）:
C16H24N2O4
化学文摘社编号:
分子量:
308.37
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[N+H3][C@@H]([C@H](O)C(=O)N[C@H](CC(C)C)C(=O)[O-])Cc1ccccc1
InChI
1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13-,14+/m1/s1
InChI key
VGGGPCQERPFHOB-MCIONIFRSA-N
description
Merck USA index - 14, 9842
assay
>99% (HPLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 2 mg/mL, methanol: 5 mg/mL
Quality Level
General description
Binds to cell surfaces and inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has antitumor properties. Also available as a 50 mM solution in water (Cat. No. 200488).
Biochem/physiol Actions
Primary Target
amino peptidase b
amino peptidase b
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). DMSO and methanol stock solutions are stable for up to 1 month at -20°C.
Unstable in aqueous solution; dilute just prior to use.
Other Notes
Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab. 79, 171.
Taylor, A., et al. 1993. Biochemistry32, 784.
Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.
Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.
Taylor, A., et al. 1993. Biochemistry32, 784.
Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.
Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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