一般描述
过氧亚硝酸盐（ONOO−）是一种强效氧化剂，由一氧化氮和超氧化物碰撞形成。
应用
过氧亚硝酸盐可用于诱导鼠大脑中的周细胞收缩。在免疫组织化学研究中，它已用于制备硝化蛋白标准品阳性对照。
生化/生理作用
过氧亚硝酸盐（ONOO−）具有杀菌活性。它促进细胞死亡，并有助于信号转导过程、线粒体功能和细胞凋亡途径。过氧亚硝酸盐的形成与各种疾病（包括血管疾病、缺血-再灌注损伤、循环休克、炎症、疼痛和神经退行性病变）的发展有关。
外形
0.3M NaOH
分析说明
通过处理未刺激的A431细胞进行常规评估。
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2
储存分类代码
8B - Non-combustible corrosive hazardous materials
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Csaba Szabó et al.
Nature reviews. Drug discovery, 6(8), 662-680 (2007-08-02)
Peroxynitrite--the product of the diffusion-controlled reaction of nitric oxide with superoxide radical--is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition
L Zhu et al.
Archives of biochemistry and biophysics, 298(2), 452-457 (1992-11-01)
Peroxynitrite is a strong oxidant formed by macrophages and potentially by other cells that produce nitric oxide and superoxide. Peroxynitrite was highly bactericidal, killing Escherichia coli in direct proportion to its concentration with an LD50 of 250 microM at 37
A Patel et al.
Journal of endocrinological investigation, 25(8), 675-683 (2002-09-21)
Nitric oxide (NO) is a reactive cell signal that controls vascular tone and is generated by inducible (iNOS), endothelial (eNOS) and neuronal (nNOS) NO synthase (NOS). We hypothesized that NO could be important for growth of thyroid tumors and tested
Pathological implications of nitric oxide, superoxide and peroxynitrite formation.
Beckman, J S and Crow, J P
Biochemical Society Transactions, 21, 330-334 (1993)
P Zhang et al.
The Journal of biological chemistry, 275(29), 22479-22486 (2000-05-10)
Activation of ERK-1 and -2 by H(2)O(2) in a variety of cell types requires epidermal growth factor receptor (EGFR) phosphorylation. In this study, we investigated the activation of ERK by ONOO(-) in cultured rat lung myofibroblasts. Western blot analysis using
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