2011
胆红素
solid, bile pigment, Calbiochem®
别名:
胆红素
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关于此项目
经验公式（希尔记法）:
C33H36N4O6
化学文摘社编号:
分子量:
584.66
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
胆红素, Principal pigment of bile and one of the major end products of hemoglobin decomposition.
Quality Level
description
RTECS - DU3038000
Merck USA index - 14, 1218
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
red-brown
solubility
chloroform: 1 mg/mL, alkaline solution: soluble
shipped in
ambient
storage temp.
10-30°C
SMILES string
[nH]1c(c(c(c1\C=C4/NC(=O)C(=C/4C)C=C)C)CCC(=O)O)Cc2[nH]c(c(c2CCC(=O)O)C)\C=C3/NC(=O)C(=C/3C=C)C
InChI
1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
InChI key
BPYKTIZUTYGOLE-IFADSCNNSA-N
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相关类别
General description
胆红素是橙黄色的胆汁色素，是血红蛋白降解的主要代谢终产物之一。含有共轭双键和活泼氢原子。对于成人，正常范围内的胆红素浓度上限为>1mg/dL。新生儿的血清胆红素水平小于15 mg/dl。本品是未结合胆红素。
Biochem/physiol Actions
据报道，胆红素可穿过血脑屏障，在脑中发挥重要的抗氧化作用。各种黄疸的变色症状中都有胆红素参与。胆红素水平可作为肝脏和血液病的生物标志物。低浓度的未结合胆红素可作为生理抗氧化剂，但胆红素浓度过高会产生毒性，导致新生儿高胆红素血症。
Preparation Note
碱性溶液中不稳定；临用前复溶。
Other Notes
消光系数(454 nm, CHCl3)：59,100-62,300 M-1cm-1。
细胞渗透性：否
可逆：否
产物不与ATP竞争。
主要靶标
细胞渗透性：否
可逆：否
产物不与ATP竞争。
主要靶标
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
R Stocker et al.
Science (New York, N.Y.), 235(4792), 1043-1046 (1987-02-27)
Bilirubin, the end product of heme catabolism in mammals, is generally regarded as a potentially cytotoxic, lipid-soluble waste product that needs to be excreted. However, it is here that bilirubin, at micromolar concentrations in vitro, efficiently scavenges peroxyl radicals generated
Jürgen Reingruber et al.
The Journal of physiology, 598(17), 3747-3763 (2020-06-20)
Most vertebrate eyes have rods for dim-light vision and cones for brighter light and higher temporal sensitivity. Rods evolved from cone-like precursors through expression of different transduction genes or the same genes at different expression levels, but we do not
Sana Ullah et al.
Iranian journal of public health, 45(5), 558-568 (2016-07-12)
Hyperbilirubinemia, or jaundice, is a life threatening disorder in newborns. It is a multifactorial disorder with many symptoms. Generally, the physiological jaundice is the most prevalent type however in some regions pathological jaundice is also common. This review article focuses
Elisabeth Lobner et al.
Frontiers in bioengineering and biotechnology, 8, 49-49 (2020-03-03)
The transmembrane protein CD19 is exclusively expressed on normal and malignant B cells and therefore constitutes the target of approved CAR-T cell-based cancer immunotherapies. Current efforts to assess CAR-T cell functionality in a quantitative fashion both in vitro and in
E Jiménez et al.
Environmental toxicology and pharmacology, 80, 103464-103464 (2020-08-05)
The identification of substances that prevent or minimize the detrimental effects of ionizing radiation is an essential undertaking. The aim of this paper was to evaluate and compare the radioprotective potential of chlorophyllin, protoporphyrin and bilirubin, with amifostine®, an US
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| GF78800452-5EA | 04061831018998 |
| GF31944416-1EA | 04061825459035 |
| GF20102465-5EA | 04061831012705 |
| GF73870476-2EA | 04061829966539 |
| GF20102465-2EA | 04061829962661 |
| GF20102465-1EA | 04061825430652 |
| GF31944416-2EA | 04061829971267 |
| GF73870476-1EA | 04061825442419 |
| GF73870476-5EA | 04061831018615 |
| GF78800452-2EA | 04061829967208 |
| GF78800452-1EA | 04061825451602 |
| 8082649025 | 04027269053895 |
| 8082642500 | 04027269066840 |
| 33427-5ML-R | 04061826737927 |
| T39853-250G | 04061837345258 |
| 89870-500ML | 04061838177445 |
| T39853-100G | 04061837345234 |
| T39853-5KG | 04061833613856 |
| 216836-1KG | 04061837506741 |
| 216836-250G | 04061838774651 |
| 89870-100ML | 04061833077153 |
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