203297-M
Bisindolylmaleimide IV
A potent, cell permeable, and selective inhibitor of protein kinase C (IC50 = 87 nM).
别名:
Bisindolylmaleimide IV, Arcyriarubin A, 2,3- bis(1H-Indol-3-yl)maleimide, Ro 31-6233
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关于此项目
经验公式（希尔记法）:
C20H13N3O2
化学文摘社编号:
分子量:
327.34
UNSPSC Code:
12352111
MDL number:
NACRES:
NA.77
SMILES string
N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([nH]c2)cccc3
InChI
1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
InChI key
DQYBRTASHMYDJG-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder, solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
dark orange
solubility
methanol: 10 mg/mL
Quality Level
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General description
A cell-permeable potent and selective inhibitor of protein kinase C (IC50 = 87 nM) and protein kinase A (IC50 = 2.7 µM).
A potent, cell permeable, and selective inhibitor of protein kinase C (IC50 = 87 nM). Inhibits protein kinase A at much higher concentrations (IC50 = 2.7 µM).
Biochem/physiol Actions
Primary Target
PKC
PKC
Target IC50: 87 nM against protein kinase C
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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