203701
bpV(HOpic)
A potent phosphotyrosine phosphatase inhibitor.
别名:
bpV(HOpic), 双过氧（5-羟基吡啶-2-羧基）氧钒酸（V）二钾, PTEN抑制剂III，PTP抑制剂XV
assay
≥70% (51V-NMR)
form
solid
potency
14 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
water: 4 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
相关类别
General description
一种有效的磷酸酪氨酸磷酸酶抑制剂。激活肝癌细胞的胰岛素受体激酶（IRK）。还刺激分离的脂肪细胞中的脂肪生成。还报道了有效抑制PTEN（IC50=14 nM）。
Biochem/physiol Actions
主要靶标
PTEN
PTEN
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Packaging
用惰性气体包装
Preparation Note
溶液中不稳定；仅在使用前进行复溶。
Other Notes
Schmid, A.C., et al. 2004.FEBS Lett.566, 35.
Posner, B.I., et al. 1994.J. Biol. Chem. 269, 4596.
Posner, B.I., et al. 1994.J. Biol. Chem. 269, 4596.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Zeinab Ghezelayagh et al.
Journal of assisted reproduction and genetics, 39(8), 1739-1747 (2022-07-13)
The effect of PTEN inhibitor (Bpv(HOpic); Bpv) and mTOR activators (phosphatidic acid (PA) and propranolol (PP)), were evaluated on the activation and subsequent development of human primordial follicles in ovarian tissue culture. Slow frozen-thawed human ovarian cortical strips were incubated
Amit Kumar et al.
Molecular and cellular biology, 44(7), 261-272 (2024-06-03)
The protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1 (SHP-1) plays an important role in modulating glucose and lipid homeostasis. We previously suggested a potential role of SHP-1 in the regulation of peroxisome proliferator-activated receptor γ2 (PPARγ2) expression and
Cyrine Ben Dhaou et al.
Angiogenesis (2021-09-16)
Chemerin is a multifunctional protein initially characterized in our laboratory as a chemoattractant factor for leukocyte populations. Its main functional receptor is CMKLR1. We identified previously chemerin as an anti-tumoral factor inhibiting the vascularization of tumor grafts. We show here
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