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Merck
CN

203729

Brefeldin A

Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function.

别名:

(+)-Brefeldin A，来源于布雷正青霉菌, 1,6,7,8,9,11a,12,13,14,14a-十氢-1,13-二羟基-6-甲基-4H-环戊[f]氧杂环十三烷-4-酮（布雷非德菌素 A）

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关于此项目

经验公式（希尔记法）:
C16H24O4
化学文摘社编号:
20350-15-6
分子量:
280.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD12913297

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产品名称

(+)-Brefeldin A，来源于布雷正青霉菌, Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function.

SMILES string

O1[C@H](CCC\C=C\[C@H]2[C@H]([C@H](\C=C\C1=O)O)C[C@H](C2)O)C

InChI

1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15-/m0/s1

InChI key

KQNZDYYTLMIZCT-PNFJWZTBSA-N

description

Merck USA index - 14, 1369

assay

≥95% (HPLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

methanol: 2 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

相关类别

Biochem/physiol Actions

主要目的
阻断蛋白质从内质网（ER）向高尔基体转运
产品不与ATP竞争。
可逆性：是
细胞渗透性：否

Disclaimer

毒性：有害（C）

General description

特异且可逆地阻断蛋白质从内质网（ER）向高尔基体转运，而不影响内吞或溶酶体功能。HDL介导的胆固醇外流的抑制剂。<40 ng/ml. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Also available as a 25 mM solution in DMSO (Cat. No. 500583可导致多种哺乳动物细胞中的高尔基体解体和ER肿胀。

Other Notes

Yamagi, R., et al. 2000.Proc.Natl.Acad.Sci. USA 97, 2567.
Moriango, N., et al. 1996.Proc.Natl.Acad.Sci. USA 93, 12856.
Mendez, A.J.1995.J. Biol. Chem. 270, 5891.
Ridgway, N.D., et al. 1995.J. Biol. Chem. 270, 8023.
Tsai, S.C., et al. 1994.Proc.Natl.Acad.Sci. USA91, 3063.
Ktistakis, N.Y., et al. 1992.Nature356, 344.

Preparation Note

溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存2个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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