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203732

Brevetoxin PbTx-2

Name: Brevetoxin PbTx-2
Brand: MM

from Ptychodiscus brevis, ≥95% (HPLC), solid, Na+ channel-binding neurotoxin, Calbiochem^®

别名:

Brevetoxin PbTx-2, Ptychodiscus brevis, Brevetoxin B, GbTx-2

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关于此项目

经验公式（希尔记法）:

C₅₀H₇₀O₁₄

化学文摘社编号:

79580-28-2

分子量:

895.08

MDL number:

MFCD00214092

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze

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属性

产品名称

Brevetoxin PbTx-2, Ptychodiscus brevis, Lipid-soluble polyether neurotoxin that binds to Na⁺ channels on nerves and muscles causing an excessive influx of Na⁺ across membranes.

Quality Segment

100

description

RTECS - XW5886000

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

tan to white

solubility

ethyl acetate: soluble, methanol: soluble, water: soluble

shipped in

wet ice

storage temp.

−20°C

SMILES string

O1C2(C(OC8(C(OC9C(OC%10C(OC%11(C(OC(CC%11O)CC(=C)C=O)C%10)C)C9)\C=C/C8)C2)C)CC3OC4C(OC5C(OC6C(OC7C(OC(=O)C=C7C)C6)(C5)C)CC4C)CCC31C)C

InChI

1S/C50H70O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,24,26,28-42,44-45,52H,1,11-15,17-23H2,2-8H3/b10-9-

InChI key

LYTCVQQGCSNFJU-KTKRTIGZSA-N

说明

General description

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na⁺ channel activator that causes contractile paralysis in animal models. The excitatory action on nerve and muscle membranes is responsible for a wide spectrum of toxic effects, including massive transmitter release from nerve endings, muscle fasiculation, and ventricular fibrillation. The excitatory action is due to opening of the Na⁺ channels. The toxin does not bind either to the TTX or to the aconitine/veratridine sites.

Lipid-soluble polyether neurotoxin that binds to Na⁺ channels on nerves and muscles causing an excessive influx of Na⁺ across membranes. Binds at site 5 on the voltage-sensitive Na⁺ channel.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Neurotoxin that binds to Na+ channels on nerves and muscles.

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

yes

Preparation Note

Following reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

From Catalog:

Solubitlity- removed acetone, EtOAc

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Edwards, R.A., et al. 1992. Mol. Brain Res.14, 64.
Trainer, V.L. 1991. Mol. Pharmacol.40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol.103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series418, 166.
Baden, G. 1989. FASEB J.3, 1807.
Baden, D.G., et al. 1988. Toxicon26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol.30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc.108, 514.
Nakanishi, K. 1985. Toxicon23, 473.
Baden, D.G., et al. 1982. Toxicon19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol.19, 345.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

象形图

GHS06

警示词

Danger

危险代码

H300 + H310 + H330

预防性声明

P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

怎么回事？

WGK 3

闪点 (F)

Not applicable

闪点 (°C)