BTS

A potent inhibitor of Ca²⁺-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.

An aryl sulphonamide that acts as a potent inhibitor of Ca²⁺-stimulated myosin S1 actin-stimulated ATPase activity (IC₅₀ = ~5 µM). Also blocks actin-stimulated ATPase activity with similar potency (IC₅₀ = 5 µM). Reversibly blocks gliding motility of skeletal muscle myosin (IC₅₀<2 µM). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.

Cell permeable: no

Primary Target
Ca²⁺-stimulated myosin S1 ATPase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: ~5 µM against Ca2+-stimulated myosin S1 ATPase

Packaged under inert gas

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Cheung, A., et al. 2002. Nat. Cell Biol.4, 83.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)