203895
BTS
≥95% (HPLC), Ca2+-stimulated myosin S1 ATPase inhibitor, crystalline solid
别名:
BTS, N-Benzyl- p-toluenesulphonamide, N-Benzyl-p-toluenesulphonamide
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关于此项目
经验公式（希尔记法）:
C14H15NO2S
化学文摘社编号:
分子量:
261.34
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
BTS, A potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 = ~ 5 µM) and reversibly blocks the gliding motility.
SMILES string
[S](=O)(=O)(NCc2ccccc2)c1ccc(cc1)C
InChI
1S/C14H15NO2S/c1-12-7-9-14(10-8-12)18(16,17)15-11-13-5-3-2-4-6-13/h2-10,15H,11H2,1H3
InChI key
WTHKAJZQYNKTCJ-UHFFFAOYSA-N
description
RTECS - XT5490000
assay
≥95% (HPLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 200 mg/mL
shipped in
ambient
Quality Level
General description
A potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 = ~ 5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.
An aryl sulphonamide that acts as a potent inhibitor of Ca2+-stimulated myosin S1 actin-stimulated ATPase activity (IC50 = ~5 µM). Also blocks actin-stimulated ATPase activity with similar potency (IC50 = 5 µM). Reversibly blocks gliding motility of skeletal muscle myosin (IC50<2 µM). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Ca2+-stimulated myosin S1 ATPase
Ca2+-stimulated myosin S1 ATPase
Product does not compete with ATP.
Reversible: yes
Target IC50: ~5 µM against Ca2+-stimulated myosin S1 ATPase
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Cheung, A., et al. 2002. Nat. Cell Biol.4, 83.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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