跳转至内容
Merck
CN

204001

BX-795 hydrochloride

BX-795, also referenced under CAS 702675-74-9, modulates the biological activity of multiple kinases. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

BX-795, AMPK相关激酶5抑制剂I，ARK5抑制剂I，NUAK激酶抑制剂I，NUAK1抑制剂I，SnF1类激酶-1抑制剂I，N-(3-((5-碘-4-((3-(2-噻吩基羰基)氨基)丙基)氨基)-2-嘧啶基)氨基)苯基)-1-吡咯烷甲酰胺，极光激酶

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C23H26IN7O2S
化学文摘社编号:
702675-74-9
分子量:
591.47
MDL number:
MFCD12546134
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
protect from light

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

BX-795, BX-795, also referenced under CAS 702675-74-9, modulates the biological activity of multiple kinases. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

SMILES string

Ic1c(nc(nc1)Nc3cc(ccc3)NC(=O)N4CCCC4)NCCCNC(=O)c2[s]ccc2

InChI

1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)

InChI key

VAVXGGRQQJZYBL-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

相关类别

Disclaimer

毒性：标准处理（A）

General description

一种可渗透细胞的氨基嘧啶化合物，可作为有效的，ATP竞争性和可逆的多激酶抑制剂（在≤ 10 µM ATP下，PDK1的IC50=11 nM；对于NUAK1，TBK1，MARK4，Aurora B，IKKε和PDK1，在100 µM ATP下，IC50=5、6、19、31、41和111 nM），并且显示出比Cdk2/E、EGFR、GSK-3β、IR、c-Kit、PKA、PKC、TAK1和VEGFR高50倍的选择性。显示可阻断PDK1/Akt信号传导，诱导PC-3和MDA-468细胞的生长停滞和凋亡（IC50分别为0.25和0.75 µM）；此外，抑制IRF3的磷酸化（pSer396），核转位和转录活性，并减少刺激的巨噬细胞中IFN-β的产生。

Other Notes

Clark, K., et al. 2009.J. Biol. Chem.284, 14136.
Tamgumcy, T., et al. 2008.Exp.Cell Res.314, 2299.
Feldman, R.I., et al. 2005.J. Biol. Chem.280, 19867.

Packaging

用惰性气体包装

Preparation Note

复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Sarah A Scuderi et al.
Oncology research, 28(7), 779-790 (2021-03-21)
Glioma are common malignant brain tumors, among which glioblastoma multiforme (GBM) has the worst prognosis. Different studies of GBM revealed that targeting nuclear factor B (NF-B) induced an attenuation tumor proliferation and prolonged cell survival. TBK1 {TANK [TRAF (TNF (tumor-necrosis-factor)
Lianxin Hu et al.
Cancer discovery, 10(3), 460-475 (2019-12-08)
TANK binding kinase 1 (TBK1) is an important kinase involved in the innate immune response. Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. Tumors from patients with kidney cancer with VHL

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持