Complement C3a des-Arg, Human

Native, human des-Arg C3 complement component. Single chain, 76 amino acid peptide. Once the C3a peptide has been produced in human plasma or serum, it is rapidly converted to C3a des-Arg upon removal of the C-terminal arginine by endogenous serum carboxypeptidase N. This enzymatic process is considered to be a major mechanism for controlling C3a function in vivo because C3a des-Arg has <1% of the biological activity expressed by the C3a peptide. Therefore, C3a des-Arg can serve as a negative control molecule in experiments involved with the biological activities of the intact C3a anaphylatoxin peptide.

Ileum contraction assay: negative

Please refer to vial label for lot-specific concentration.

In PBS, pH 7.2.

Following initial thaw, aliquot and freeze (-70°C).

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Kajita, T. and Hugli, T.E. 1991. Am. J. Pathol. 138, 1359.
Bokish, V.A. and Muller-Eberhard, H.J. 1970. J. Clin. Invest.49, 2427.

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Toxicity: Standard Handling (A)