质量水平
方案
≥97% (HPLC)
表单
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
yellow
溶解性
DMSO: 100 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
FC1=CC=CC(F)=C1C[N+](CC2)=C(C3=C2C=C(C(OC)=C3)OC)CCCCCCCCCCCCCCC.[I-]
一般描述
A cell-permeable isoquinolinium compound that preferentially induces apoptotic cell death in p53-deficient cancer cells with functional MMR (DNA mismatch repair) system, including HCT116-Ch3/E6, HeLa, HT29, and SW620 (viability <19 %; 4-6 µM Cadein1 for 24 h), while exhibiting much reduced potency in MMR-/p53+ (RKO and HCT116), MMR-/p53- (DLD-1 and HCT116-E6), and MMR+/p53+ (HCT116-Ch3 and HEK293) cancer cultures (viability = 40 to 92%; 4 µM Cadein1 for 24 h).
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Jang, E.R., et al. 2010. J. Biol. Chem.285, 2986.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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