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Merck
CN

205548

Sigma-Aldrich

Caffeine

≥99% (HPLC), central nervous system stimulant, solid

别名:

Caffeine, 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

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关于此项目

经验公式(希尔记法):
C8H10N4O2
化学文摘社编号:
分子量:
194.19
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
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产品名称

Caffeine, Trimethylated xanthine that acts as a potent central nervous system stimulant.

描述

Merck USA index - 14, 1636

质量水平

方案

≥99% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

white

溶解性

chloroform: 50 mg/mL

运输

ambient

储存温度

10-30°C

SMILES字符串

[n]1(c2c(nc1)N(C(=O)N(C2=O)C)C)C

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

一般描述

Trimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by Camptothecin (Cat. No. 208925) and topotecan in HL-60 cells.

生化/生理作用

Cell permeable: no
Primary Target
Potent central nervous system stimulant
Product does not compete with ATP.
Reversible: no

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Zhen, W., and Vaugha, A. T. 1995. Radiat. Res.141, 170.
Howell, L. L. 1993. Cancer Res.54, 4993.
Traganos, F., et al. 1993. Cancer Res.53, 4613.
Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Harmful (C)

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 1

法规信息

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Han Hu et al.
Cardiovascular research, 116(5), 944-955 (2019-08-03)
The elevated expression of phospholamban (PLB) has been observed in heart failure and cardiac remodelling, inhibiting the affinity of Ca2+ pump to Ca2+ thereby impairing heart relaxation. However, the mechanisms underlying the regulation of PLB remains to be further studied.
Kurtis Stefan et al.
BMC genomics, 24(1), 253-253 (2023-05-12)
Cis-regulatory elements (CRE) are critical for coordinating gene expression programs that dictate cell-specific differentiation and homeostasis. Recently developed self-transcribing active regulatory region sequencing (STARR-Seq) has allowed for genome-wide annotation of functional CREs. Despite this, STARR-Seq assays are only employed in

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