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Merck
CN

208722

钙蛋白酶抑制剂 III

≥95% (HPLC), calpain I and II inhibitor, lyophilized solid

别名:

钙蛋白酶抑制剂 III, 苄氧羰基-缬氨酸-苯丙氨酸,MDL 28170

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关于此项目

经验公式(希尔记法):
C22H26N2O4
化学文摘社编号:
分子量:
382.45
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Quality level:
Storage condition:
OK to freeze
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产品名称

钙蛋白酶抑制剂 III, The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

SMILES string

N([C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C=O)C(=O)OCc1ccccc1

InChI

1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1

InChI key

NGBKFLTYGSREKK-PMACEKPBSA-N

assay

≥95% (HPLC)

form

lyophilized solid

potency

8 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 20 mg/mL (Use only anhydrous DMSO.)

shipped in

ambient

storage temp.

2-8°C

Quality Level

Biochem/physiol Actions

主要靶标
钙蛋白酶1,钙蛋白酶2
产物不与ATP竞争。
可逆:否
细胞可渗透性:是

Disclaimer

毒性:标准处理(A)

General description

一种有效的细胞渗透性钙蛋白酶I和II抑制剂(Ki = 8 nM),还可减少培养的背根神经节中辣椒素介导的细胞死亡。据报道,它可以阻止A23187诱导的离体海马锥体神经元神经突生长的抑制。对谷氨酸诱导的毒性表现出神经保护作用。

Other Notes

Chatterjee, S., et al. 1998.J. Med. Chem.41, 2663.
Rami, A., et al. 1997.Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997.Biochemistry36, 8377.
Klafki, H., et al. 1996.J. Biol. Chem.271, 28655.
Chard, P.S., et al. 1995.Neuroscience 65, 1099.
Song, D.K., et al. 1994.J. Neurosci. Res. 39, 474.
Z-Val-Phe-CHO

Preparation Note

复溶后,等分并冷冻保存(-20°C)。储备液可在-20°C最长稳定1个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Vimala Bondada et al.
Biochimica et biophysica acta. Molecular cell research, 1868(7), 119019-119019 (2021-04-04)
The enzymatic characteristics of the ubiquitous calpain 5 (CAPN5) remain undescribed despite its high expression in the central nervous system and links to eye development and disease. CAPN5 contains the typical protease core domains but lacks the C terminal penta-EF

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Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.

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