208722
钙蛋白酶抑制剂 III
≥95% (HPLC), calpain I and II inhibitor, lyophilized solid
别名:
钙蛋白酶抑制剂 III, 苄氧羰基-缬氨酸-苯丙氨酸，MDL 28170
登录 查看组织和合同定价。
选择规格
变更视图
关于此项目
经验公式（希尔记法）:
C22H26N2O4
化学文摘社编号:
分子量:
382.45
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Storage condition:
OK to freeze
产品名称
钙蛋白酶抑制剂 III, The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Quality Segment
assay
≥95% (HPLC)
form
lyophilized solid
potency
8 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 20 mg/mL (Use only anhydrous DMSO.)
shipped in
ambient
storage temp.
2-8°C
SMILES string
N([C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C=O)C(=O)OCc1ccccc1
InChI
1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1
InChI key
NGBKFLTYGSREKK-PMACEKPBSA-N
General description
一种有效的细胞渗透性钙蛋白酶I和II抑制剂（Ki = 8 nM），还可减少培养的背根神经节中辣椒素介导的细胞死亡。据报道，它可以阻止A23187诱导的离体海马锥体神经元神经突生长的抑制。对谷氨酸诱导的毒性表现出神经保护作用。
Biochem/physiol Actions
主要靶标
钙蛋白酶1，钙蛋白酶2
钙蛋白酶1，钙蛋白酶2
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液可在-20°C最长稳定1个月。
Other Notes
Chatterjee, S., et al. 1998.J. Med. Chem.41, 2663.
Rami, A., et al. 1997.Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997.Biochemistry36, 8377.
Klafki, H., et al. 1996.J. Biol. Chem.271, 28655.
Chard, P.S., et al. 1995.Neuroscience 65, 1099.
Song, D.K., et al. 1994.J. Neurosci. Res. 39, 474.
Rami, A., et al. 1997.Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997.Biochemistry36, 8377.
Klafki, H., et al. 1996.J. Biol. Chem.271, 28655.
Chard, P.S., et al. 1995.Neuroscience 65, 1099.
Song, D.K., et al. 1994.J. Neurosci. Res. 39, 474.
Z-Val-Phe-CHO
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable