208724
钙蛋白酶抑制剂IV
The Calpain Inhibitor IV controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
钙蛋白酶抑制剂IV, Z-LLY-FMK
产品名称
钙蛋白酶抑制剂IV, The Calpain Inhibitor IV controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
white to pale yellow
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
相关类别
Analysis Note
TLC测定单个斑点
Biochem/physiol Actions
主要靶标
钙蛋白酶2
钙蛋白酶2
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
钙蛋白酶II的抑制中，k₂ = 28,900 M⁻¹s⁻¹ ；组织蛋白酶L的抑制中，k2 = 680,000 M⁻¹s⁻¹
Disclaimer
毒性：标准处理（A）
General description
一种有效的，细胞可渗透且不可逆的钙蛋白酶II抑制剂（k2 = 28,900 M-1s-1）。还用作组织蛋白酶L的抑制剂（k2 = 680,000 M-1s-1）。
Other Notes
Dutt, P., et al. 1998.FEBS Lett.436, 367.
Angliker, H., et al. 1992.J. Med. Chem. 35, 216.
Angliker, H., et al. 1992.J. Med. Chem. 35, 216.
Z-Leu-Leu-Tyr-CH₂F
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存6个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Kirill Gorshkov et al.
ACS infectious diseases, 7(6), 1389-1408 (2020-12-22)
Understanding the SARS-CoV-2 virus' pathways of infection, virus-host-protein interactions, and mechanisms of virus-induced cytopathic effects will greatly aid in the discovery and design of new therapeutics to treat COVID-19. Chloroquine and hydroxychloroquine, extensively explored as clinical agents for COVID-19, have
Vimala Bondada et al.
Biochimica et biophysica acta. Molecular cell research, 1868(7), 119019-119019 (2021-04-04)
The enzymatic characteristics of the ubiquitous calpain 5 (CAPN5) remain undescribed despite its high expression in the central nervous system and links to eye development and disease. CAPN5 contains the typical protease core domains but lacks the C terminal penta-EF
Anna Luganini et al.
mBio, 14(4), e0074923-e0074923 (2023-07-21)
The human cytomegalovirus (HCMV) US12 gene family contributes to virus-host interactions by regulating the virus' cell tropism and its evasion of host innate immune responses. US21, one of the 10 US12 genes (US12-US21), is a descendant of a captured cellular
相关内容
Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持