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208731

Calpain Substrate II, Fluorogenic

Name: Calpain Substrate II, Fluorogenic
Brand: MM

Cyclic fluorogenic substrate for the quantitative determination of calpain -1 and -2.

别名:

Calpain Substrate II, Fluorogenic, Suc-LY-AMC

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关于此项目

经验公式（希尔记法）:

C₂₉H₃₃N₃O₈

化学文摘社编号:

94367-20-1

分子量:

551.59

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00057900

Assay:

≥95% (TLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated, protect from light

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属性

Quality Level

100

assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated, protect from light

color

off-white

solubility

DMSO: soluble

fluorescence

λ_ex ~380 nm, λ_em ~460 nm

shipped in

ambient

storage temp.

−20°C

SMILES string

N([C@@H](C(CC)C)C(=O)NC(Cc3ccc(cc3)O)C(=O)Nc1cc2c(cc1)C(=CC(=O)O2)C)C(=O)CCC(=O)O

InChI

1S/C29H33N3O8/c1-4-16(2)27(32-24(34)11-12-25(35)36)29(39)31-22(14-18-5-8-20(33)9-6-18)28(38)30-19-7-10-21-17(3)13-26(37)40-23(21)15-19/h5-10,13,15-16,22,27,33H,4,11-12,14H2,1-3H3,(H,30,38)(H,31,39)(H,32,34)(H,35,36)/t16?,22?,27-/m0/s1

InChI key

VSWNAJAOJZXWBM-FTJGSZSVSA-N

说明

General description

Cyclic fluorogenic substrate for the quantitative determination of calpain -1 and -2. Also suitable for measuring the peptidase activity of the 20S proteasome. Typical concentrations range from 10 - 100 µM, depending on assay conditions.

Fluorogenic substrate for the quantitative determination of porcine calpain I and II activity. Also serves as a substrate for other proteases including proteasome. (excitation wavelength: 380 nm; emission wavelength: 460 nm)

Biochem/physiol Actions

Cell permeable: no

Primary Target
Calpain -1 and -2

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Seol, J.H., et al. 1989. FEBS Lett. 247, 197.
Woo, K.M., et al. 1989. J. Biol. Chem. 264, 2088.
Sasaki, T., et al. 1984. J. Biol. Chem.259, 12489.

Suc-Leu-Tyr-AMC

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c