208731
Calpain Substrate II, Fluorogenic
Cyclic fluorogenic substrate for the quantitative determination of calpain -1 and -2.
别名:
Calpain Substrate II, Fluorogenic, Suc-LY-AMC
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关于此项目
经验公式（希尔记法）:
C29H33N3O8
化学文摘社编号:
分子量:
551.59
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (TLC)
Form:
solid
Storage condition:
OK to freeze, desiccated, protect from light
Quality Segment
assay
≥95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
off-white
solubility
DMSO: soluble
fluorescence
λex ~380 nm, λem ~460 nm
shipped in
ambient
storage temp.
−20°C
SMILES string
N([C@@H](C(CC)C)C(=O)NC(Cc3ccc(cc3)O)C(=O)Nc1cc2c(cc1)C(=CC(=O)O2)C)C(=O)CCC(=O)O
InChI
1S/C29H33N3O8/c1-4-16(2)27(32-24(34)11-12-25(35)36)29(39)31-22(14-18-5-8-20(33)9-6-18)28(38)30-19-7-10-21-17(3)13-26(37)40-23(21)15-19/h5-10,13,15-16,22,27,33H,4,11-12,14H2,1-3H3,(H,30,38)(H,31,39)(H,32,34)(H,35,36)/t16?,22?,27-/m0/s1
InChI key
VSWNAJAOJZXWBM-FTJGSZSVSA-N
General description
Cyclic fluorogenic substrate for the quantitative determination of calpain -1 and -2. Also suitable for measuring the peptidase activity of the 20S proteasome. Typical concentrations range from 10 - 100 µM, depending on assay conditions.
Fluorogenic substrate for the quantitative determination of porcine calpain I and II activity. Also serves as a substrate for other proteases including proteasome. (excitation wavelength: 380 nm; emission wavelength: 460 nm)
Biochem/physiol Actions
Cell permeable: no
Primary Target
Calpain -1 and -2
Calpain -1 and -2
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Seol, J.H., et al. 1989. FEBS Lett. 247, 197.
Woo, K.M., et al. 1989. J. Biol. Chem. 264, 2088.
Sasaki, T., et al. 1984. J. Biol. Chem.259, 12489.
Woo, K.M., et al. 1989. J. Biol. Chem. 264, 2088.
Sasaki, T., et al. 1984. J. Biol. Chem.259, 12489.
Suc-Leu-Tyr-AMC
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
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WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable