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Merck
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About This Item

经验公式(希尔记法):
C9H15NO3S
CAS Number:
分子量:
217.29
MDL编号:
UNSPSC代码:
12352200
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质量水平

方案

≥98% (titration)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

white to off-white

溶解性

water: 1 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChI key

FAKRSMQSSFJEIM-RQJHMYQMSA-N

一般描述

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC50= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC50 = ~ 320 nM).
An antihypertensive agent. Reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Also a competitive inhibitor of angiotensin-converting enzyme (ACE). Inhibits angiogenesis and slows the growth of experimental tumors in rats.

生化/生理作用

Cell permeable: no
Primary Target
ACE
Product does not compete with ATP.
Reversible: yes
Target IC50: 23-35 nM against angiotensin-converting enzyme (ACE); 11 µM against LTA4 hydrolase; ~ 320 nM inhibiting apoptosis in human lung epithelial cells

警告

Toxicity: Carcinogenic / Teratogenic (D)

其他说明

Uhal, B.D., et al. 1998. Am. J. Physiol.275, L1013.
Volpert, O.V., et al. 1996. J. Clin. Invest.98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Muta. 2 - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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