211875
Captopril
An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC50= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM).
别名:
Captopril, [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225
产品名称
Captopril, An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC50= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM).
InChI
1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
InChI key
FAKRSMQSSFJEIM-RQJHMYQMSA-N
assay
≥98% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to off-white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
ACE
ACE
Product does not compete with ATP.
Reversible: yes
Target IC50: 23-35 nM against angiotensin-converting enzyme (ACE); 11 µM against LTA4 hydrolase; ~ 320 nM inhibiting apoptosis in human lung epithelial cells
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
General description
An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC50= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC50 = ~ 320 nM).
An antihypertensive agent. Reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Also a competitive inhibitor of angiotensin-converting enzyme (ACE). Inhibits angiogenesis and slows the growth of experimental tumors in rats.
Other Notes
Uhal, B.D., et al. 1998. Am. J. Physiol.275, L1013.
Volpert, O.V., et al. 1996. J. Clin. Invest.98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.
Volpert, O.V., et al. 1996. J. Clin. Invest.98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Muta. 2 - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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