产品名称
羰基氰化m-氯苯腙, Protonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol.
Quality Segment
description
RTECS - FG5600000
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
yellow
solubility
ethanol: 1 mg/mL, DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Clc1cc(ccc1)NN=C(C#N)C#N
InChI
1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H
InChI key
UGTJLJZQQFGTJD-UHFFFAOYSA-N
General description
质子体。用于氧化磷酸化的解偶联剂，可抑制线粒体功能。比 2,4-二硝基苯酚有效约 100 倍。以高亲和力结合细胞色素 c 氧化酶（Kd = 270 nM）。抑制运输过程并抑制生长。
Biochem/physiol Actions
与细胞色素 c 氧化酶结合的 Kd = 270 nM
主靶
细胞色素 c 氧化酶
细胞色素 c 氧化酶
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Preparation Note
在重悬后存放于冰箱（4°C）。储备液可在4°C最长稳定1个月。
Other Notes
Bona, M., et al. 1993.Gen.Physiol.Biophys.12, 533.
Heytler, P.G., and Prichard, W.W.1962.Biochem.Biophys.Res. Commun.7, 272.
Heytler, P.G., and Prichard, W.W.1962.Biochem.Biophys.Res. Commun.7, 272.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有害（C）
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 215911-250MG | 04055977219241 |