表单
(Off-white solid)
溶解性
soluble (DMSO (10 mg/ml))
储存温度
−20°C
一般描述
A cell-permeable, potent, reversible, ATP-competitive and selective inhibitor of Cdk1/cyclin B (IC50 = 25 nM). Affects the activities of other kinases only at higher concentrations (IC50 = 6.1 µM for PKCα, 125 µM for PKA, and >10 µM for EGFR). Also reported to induce mitochondrial damage and apoptosis in several human leukemia cell lines (>3 µM). At lower concentrations (~1 µM) an initial G2M cell cycle arrest and eventual apoptosis has been reported to occur in U937 cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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