218714
Casein Kinase II Inhibitor IX, IQA
The Casein Kinase II Inhibitor IV, also referenced under CAS 391670-48-7, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Casein Kinase II Inhibitor IX, IQA, 5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
light yellow
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C17H12N2O3/c20-15(21)9-12-10-5-1-3-7-13(10)19-14-8-4-2-6-11(14)17(22)18-16(12)19/h1-8,12H,9H2,(H,20,21)
InChI key
DNABALWBHCYRNL-UHFFFAOYSA-N
一般描述
A cell-permeable indoloquinazolinone compound that acts as a potent, selective, and reversible CK2 inhibitor (IC50 = 390 nM with 100 M ATP) in an ATP- and GTP-competitive manner (Ki = 0.17 and 0.21 M, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 M) and 48 commonly studied protein kinases (IC50 ≥10 M with 100 M ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC50 = 8 and <1 M, respectively, with 100 M ATP).
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
其他说明
Piazza, F.A., et al. 2006. Blood108, 1698.
Di Maira, G., et al. 2005. Cell Death Differ.12, 668.
Sarno, S., et al. 2003. Biochem. J.374, 639.
Vangrevelinghe, E., et al. 2003. J. Med. Chem.46, 2656.
Di Maira, G., et al. 2005. Cell Death Differ.12, 668.
Sarno, S., et al. 2003. Biochem. J.374, 639.
Vangrevelinghe, E., et al. 2003. J. Med. Chem.46, 2656.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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