218714
Casein Kinase II Inhibitor IX, IQA
The Casein Kinase II Inhibitor IV, also referenced under CAS 391670-48-7, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Casein Kinase II Inhibitor IX, IQA, 5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid
InChI key
DNABALWBHCYRNL-UHFFFAOYSA-N
InChI
1S/C17H12N2O3/c20-15(21)9-12-10-5-1-3-7-13(10)19-14-8-4-2-6-11(14)17(22)18-16(12)19/h1-8,12H,9H2,(H,20,21)
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
light yellow
solubility
DMSO: 10 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable indoloquinazolinone compound that acts as a potent, selective, and reversible CK2 inhibitor (IC50 = 390 nM with 100 M ATP) in an ATP- and GTP-competitive manner (Ki = 0.17 and 0.21 M, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 M) and 48 commonly studied protein kinases (IC50 ≥10 M with 100 M ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC50 = 8 and <1 M, respectively, with 100 M ATP).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Piazza, F.A., et al. 2006. Blood108, 1698.
Di Maira, G., et al. 2005. Cell Death Differ.12, 668.
Sarno, S., et al. 2003. Biochem. J.374, 639.
Vangrevelinghe, E., et al. 2003. J. Med. Chem.46, 2656.
Di Maira, G., et al. 2005. Cell Death Differ.12, 668.
Sarno, S., et al. 2003. Biochem. J.374, 639.
Vangrevelinghe, E., et al. 2003. J. Med. Chem.46, 2656.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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