218750
Caspase-3 Inhibitor III
The Caspase-3 Inhibitor III, also referenced under CAS 285570-60-7, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
别名:
Caspase-3 Inhibitor III, Ac-DEVD-CMK
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关于此项目
经验公式（希尔记法）:
C21H31ClN4O11
化学文摘社编号:
分子量:
550.94
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.54
InChI key
ATNOUPFYBMVFLD-RSLFNQERSA-N
InChI
1S/C21H31ClN4O11/c1-9(2)18(21(37)25-12(6-16(31)32)14(28)8-22)26-19(35)11(4-5-15(29)30)24-20(36)13(7-17(33)34)23-10(3)27/h9,11-13,18H,4-8H2,1-3H3,(H,23,27)(H,24,36)(H,25,37)(H,26,35)(H,29,30)(H,31,32)(H,33,34)/t11-,12-,13-,18-/m0/s1
SMILES string
ClCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CCC(=O)O)C(C)C)CC(=O)O
assay
≥98% (HPLC)
form
lyophilized solid, powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white to off-white
solubility
20% acetonitrile: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A potent cell-permeable and irreversible inhibitor of caspase-3, a member of the ICE-CED-3 family of cysteine proteases.
A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Other Notes
Ac-Asp-Glu-Val-Asp-CMK
Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197
Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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