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218750

Caspase-3 Inhibitor III

Name: Caspase-3 Inhibitor III
Brand: MM

The Caspase-3 Inhibitor III, also referenced under CAS 285570-60-7, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

别名:

Caspase-3 Inhibitor III, Ac-DEVD-CMK

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关于此项目

经验公式（希尔记法）:

C₂₁H₃₁ClN₄O₁₁

化学文摘社编号:

285570-60-7

分子量:

550.94

MDL number:

MFCD25372552

UNSPSC Code:

12352200

NACRES:

NA.54

Assay:

≥98% (HPLC)

Form:

lyophilized solid, powder

Quality level:

100

Storage condition:

OK to freeze, desiccated

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属性

Quality Level

100

assay

≥98% (HPLC)

form

lyophilized solid, powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated

color

white to off-white

solubility

20% acetonitrile: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

ClCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CCC(=O)O)C(C)C)CC(=O)O

InChI

1S/C21H31ClN4O11/c1-9(2)18(21(37)25-12(6-16(31)32)14(28)8-22)26-19(35)11(4-5-15(29)30)24-20(36)13(7-17(33)34)23-10(3)27/h9,11-13,18H,4-8H2,1-3H3,(H,23,27)(H,24,36)(H,25,37)(H,26,35)(H,29,30)(H,31,32)(H,33,34)/t11-,12-,13-,18-/m0/s1

InChI key

ATNOUPFYBMVFLD-RSLFNQERSA-N

说明

General description

A potent cell-permeable and irreversible inhibitor of caspase-3, a member of the ICE-CED-3 family of cysteine proteases.

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Ac-Asp-Glu-Val-Asp-CMK

Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197
Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c