218765
Caspase-9 Substrate I, Fluorogenic
A fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6).
别名:
Caspase-9 Substrate I, Fluorogenic, Ac-LEHD-AFC
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关于此项目
经验公式（希尔记法）:
C33H38F3N7O11
化学文摘社编号:
分子量:
765.69
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
InChI key
HULKIXRFKRCRHD-ZJZGAYNASA-N
InChI
1S/C33H38F3N7O11/c1-15(2)8-22(39-16(3)44)31(52)41-21(6-7-26(45)46)29(50)42-23(9-18-13-37-14-38-18)32(53)43-24(12-27(47)48)30(51)40-17-4-5-19-20(33(34,35)36)11-28(49)54-25(19)10-17/h4-5,10-11,13-15,21-24H,6-9,12H2,1-3H3,(H,37,38)(H,39,44)(H,40,51)(H,41,52)
SMILES string
FC(F)(F)C1=CC(=O)Oc2c1ccc(c2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CCC(=O)O)Cc3[nH]cnc3)CC(=O)O
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
white
solubility
DMSO: 5 mg/mL
fluorescence
λex ~400 nm, λem ~505 nm
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6). May also act as a substrate for caspase-4 and caspase-5. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
Biochem/physiol Actions
Cell permeable: no
Primary Target
A fluorogenic substrate for caspase-9
A fluorogenic substrate for caspase-9
Product does not compete with ATP.
Reversible: no
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Ac-Leu-Glu-His-Asp-AFC
Ito, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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