A cell-permeable, irreversible, and general caspase inhibitor. Also reported to inhibit Peptide: N-glycanase (PNGase) in vitro and in vivo. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies.

Cell permeable: yes

Primary Target
general caspase inhibitor

Product does not compete with ATP.

Reversible: no

Packaged under inert gas

Toxicity: Irritant (B)

Z-Val-Ala-Asp-CH₂F*

A 10 mM (1 mg/221 µl) solution of Caspase Inhibitor VI (Cat. No. 219007) in DMSO.

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.

Misaghi, S., et al. 2004. Chem. Biol.11, 1677.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany