219012
Caspase-3 Inhibitor VII
The Caspase-3 Inhibitor VII, also referenced under CAS 745046-84-8, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
别名:
Caspase-3 Inhibitor VII, 2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
产品名称
Caspase-3 Inhibitor VII, The Caspase-3 Inhibitor VII, also referenced under CAS 745046-84-8, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
InChI key
MWXJJTMEUGWKKY-UHFFFAOYSA-N
InChI
1S/C20H21N3O7S/c1-12-17-18(20(26)23(19(17)25)7-10-30-13(2)24)15-11-14(3-4-16(15)21-12)31(27,28)22-5-8-29-9-6-22/h3-4,11H,5-10H2,1-2H3
assay
≥95% (HPLC)
form
solid
potency
23 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Biochem/physiol Actions
Cell permeable: yes
Primary Target
capase-3
capase-3
Product does not compete with ATP.
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
Other Notes
Kravchenko, D.V., et al. 2005. J. Med. Chem.48, 3680.
Packaging
Packaged under inert gas
General description
A cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with 10-100-fold greater selectivity. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in a model of Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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