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经验公式(希尔记法):
C13H10Cl2N2O4S
化学文摘社编号:
分子量:
361.20
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
[S](=O)(=O)(Nc2c(cc(cc2)[N+](=O)[O-])C)c1c(ccc(c1)Cl)Cl
InChI
1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3
InChI key
AXNUEXXEQGQWPA-UHFFFAOYSA-N
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 100 mg/mL
shipped in
ambient
Quality Level
General description
一种可渗透细胞的磺酰胺化合物,可作为Wnt/β-连环蛋白(在β-连环蛋白/TCF依赖性细胞报告基因分析中,在15 µM时抑制≥80%)和PPARγ/δ(在PPRE细胞报告基因中,在0.5 µM时抑制≥30%)信号传导的双重途径抑制剂。尽管FH535和结构相似的PPARγ-选择性抑制剂GW9662(目录编号370700)均抑制共激活剂/PPAR结合,但只有FH535阻断β-连环蛋白/PPARγ相互作用,并且FH535的拮抗活性不涉及对GW9662作用至关重要的PPAR配体结合位点半胱氨酸残基的共价修饰或非共价相互作用。
Packaging
用惰性气体包装
Preparation Note
复溶后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存3个月。
Other Notes
Handeli, S., and Simon, J.A.2008.Mol.Cancer Ther.7, 521.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性:标准处理(A)
存储类别
11 - Combustible Solids
wgk
WGK 3
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