219334
β-Catenin/Tcf Inhibitor V
BC21
别名:
β-Catenin/Tcf Inhibitor V, ICAT, Inhibitor of beta-catenin and Tcf
form
(Dark brown solid)
solubility
soluble (DMSO (0.5 mg/ml). Poorly soluble in water.)
storage temp.
2-8°C
Quality Level
General description
A cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2
存储类别
8B - Non-combustible corrosive hazardous materials
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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