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Merck
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About This Item

经验公式(希尔记法):
C16H16N5NaO7S2
CAS Number:
分子量:
477.45
Beilstein:
5711411
MDL编号:
UNSPSC代码:
12352200
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方案

≥91% dry basis (HPLC)

表单

crystalline solid

旋光性

[α]/D +58 to +64°, c = 1 in H2O

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

颜色

white

溶解性

water: 250 mg/mL

运输

ambient

储存温度

15-25°C

SMILES字符串

[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O

InChI

1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1

InChI key

AZZMGZXNTDTSME-JUZDKLSSSA-M

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一般描述

Potent β-lactamase-resistant antibiotic of cephalosporin class. Active against gram-positive and gram-negative organisms, including gram-negative anaerobes. Inhibits cell wall synthesis. Has an optimal pH of 4.5-6.5.

生化/生理作用

Mode of Action: Inhibits bacterial cell wall synthesis.
Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

重悬

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 10 days at 4°C or for up to 13 weeks at -20°C.

其他说明

Broad spectrum third generation cephalosporin antibiotic.
Molinari, G., et al. 1991. J. Chemotherap. 3, 6.
Vallee, F., and LeBel, M. 1991. Antimicrob. Agents Chemother. 35, 2057.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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