219433
Cathepsin L Inhibitor IV
The Cathepsin L Inhibitor IV controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
Cathepsin L Inhibitor IV, 1-Naphthalenesulfonyl-IW-CHO
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About This Item
经验公式（希尔记法）:
C27H29N3O4S
分子量:
491.60
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white to off-white
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
−20°C
一般描述
A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50 = 1.9 nM). Also inhibits the release of Ca2+ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
生化/生理作用
Cell permeable: yes
Primary Target
cathepsin L
cathepsin L
Product does not compete with ATP.
Reversible: yes
Target IC50: 1.9 nM against Cathepsin L
警告
Toxicity: Standard Handling (A)
序列
1-Naphthalenesulfonyl-Ile-Trp-CHO
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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