219477
Cdk4 Inhibitor II, NSC 625987
The Cdk4 Inhibitor II, NSC 625987, also referenced under CAS 141992-47-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Cdk4 Inhibitor II, NSC 625987, 1,4-Dimethoxyacridine-9(10H)-thione
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关于此项目
经验公式（希尔记法）:
C15H13NO2S
化学文摘社编号:
分子量:
271.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
S=[c]1c2c([nH]c3c1cccc3)c(ccc2OC)OC
InChI
1S/C15H13NO2S/c1-17-11-7-8-12(18-2)14-13(11)15(19)9-5-3-4-6-10(9)16-14/h3-8H,1-2H3,(H,16,19)
InChI key
KFAKESMKRPNZTM-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
brown
solubility
ethanol: 2.5 mg/mL, DMSO: 25 mg/mL
shipped in
ambient
Quality Level
General description
A potent, reversible, and substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 >100 µM).
A thioacridone compound that acts as a reversible and potent substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 >100 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
CDK4/D1
CDK4/D1
Product does not compete with ATP.
Reversible: yes
Target IC50: 200 nM against CDK4/D1
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Kubo, A., et al. 1999. Clin. Cancer Res.5, 4279.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
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