219482
小窝蛋白1脚手架区结构域多肽，细胞渗透型
Caveolin-1 scaffolding domain peptide (C1-SD82-101) fused at the N-terminus to the cell-permeable Antennapedia internalization sequence (43-58).
别名:
小窝蛋白1脚手架区结构域多肽，细胞渗透型, AP-Cav, Pen-C1-SD, RQIKIWFQNRRMKWKK-DGIWKASFTTFTVTKYWFYR, Cavtratin
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
DMSO: 2 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
小窝蛋白-1支架结构域肽（C1-SD82-101）在N端与细胞可渗透的触角内化序列融合（43-58）。据报道，该肽在体外可阻断eNOS活性和细胞NO释放，并减少体内炎症和肿瘤发生。小窝蛋白-1通过C1-SD82-101序列与几种脂质修饰的信号配体相互作用，例如EGFR，eNOS，G蛋白α-亚基，PKCα，H-Ras和Src。
Biochem/physiol Actions
主要靶标
eNOS
eNOS
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
Packaging
用惰性气体包装
Physical form
作为三氟乙酸盐提供。
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。
Other Notes
Bernatchez, P.N., et al. 2005.Proc.Natl.Acad.Sci. USA102, 761.
Williams, T.M., et al. 2004.J. Biol. Chem.279, 51630.
Gratton, J.P., et al. 2003.Cancer Cell4, 31.
Sukumaran, S.K., et al. 2002.J. Biol. Chem.277, 50716.
Liu, J., et al. 2002.J. Biol. Chem.277, 10661.
Bucci, M., et al. 2000.Nat. Med.6, 1362.
Okamoto, T., et al. 1998.J. Biol. Chem.273, 5419.
Williams, T.M., et al. 2004.J. Biol. Chem.279, 51630.
Gratton, J.P., et al. 2003.Cancer Cell4, 31.
Sukumaran, S.K., et al. 2002.J. Biol. Chem.277, 50716.
Liu, J., et al. 2002.J. Biol. Chem.277, 10661.
Bucci, M., et al. 2000.Nat. Med.6, 1362.
Okamoto, T., et al. 1998.J. Biol. Chem.273, 5419.
H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：致癌/致畸（D）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Anand Sripada et al.
PLoS biology, 19(3), e3001063-e3001063 (2021-03-09)
The function of Sprouty2 (Spry2) in T cells is unknown. Using 2 different (inducible and T cell-targeted) knockout mouse strains, we found that Spry2 positively regulated extracellular signal-regulated kinase 1/2 (ERK1/2) signaling by modulating the activity of LCK. Spry2-/- CD4+
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