219504
Cefotaxime sodium salt 钠盐
≥97% (HPLC), suitable for cell culture
别名:
Cefotaxim sodium salt 钠盐
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关于此项目
经验公式（希尔记法）:
C16H16N5NaO7S2
化学文摘社编号:
分子量:
477.45
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
5711411
MDL number:
InChI
1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
SMILES string
[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O
InChI key
AZZMGZXNTDTSME-JUZDKLSSSA-M
assay
≥97% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
technique(s)
cell culture | mammalian: suitable
color
white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
15-25°C
Quality Level
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General description
Potent β-lactamase-resistant antibiotic of cephalosporin class. Active against Gram-positive and Gram-negative organisms, including Gram-negative anaerobes. Inhibits cell wall synthesis.
Biochem/physiol Actions
Mode of Action: Inhibits bacterial cell wall synthesis.
Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Primary Target
Gram-positive
Gram-positive
Secondary Target
Gram-negative
Gram-negative
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Broad spectrum third generation cephalosporin antibiotic.
Molinari, G., et al. 1991. J. Chemotherap.3, 6.
Vallee, F., and LeBel, M. 1991. Antimicrob. Agents Chemother.35, 2057.
Vallee, F., and LeBel, M. 1991. Antimicrob. Agents Chemother.35, 2057.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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