219557
Cerulenin
from Cephalosporium caerulens, ≥98% (TLC), solid, de novo phospholipid synthesis inhibito, Calbiochem
别名:
浅蓝菌素， 来源于头孢霉
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C12H17NO3
化学文摘社编号:
分子量:
223.27
UNSPSC Code:
41106500
NACRES:
NA.77
MDL number:
产品名称
浅蓝菌素， 来源于头孢霉, An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis.
Quality Level
SMILES string
NC(=O)[C@@H]1O[C@@H]1C(=O)CC\C=C\C\C=C\C
InChI
1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1
InChI key
GVEZIHKRYBHEFX-NQQPLRFYSA-N
description
Merck USA index - 14, 2004
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white to off-white
solubility
DMSO: 10 mg/mL
ethanol: 5 mg/mL
acetone: soluble
shipped in
ambient
storage temp.
2-8°C
Biochem/physiol Actions
主靶
萜烯 & 脂肪酸的生物合成
萜烯 & 脂肪酸的生物合成
Disclaimer
毒性：有害（C）
General description
一种抗真菌抗生素，可抑制固醇和脂肪酸的生物合成。在脂肪酸合成中，据报道以等摩尔比结合 β-酮-酰基-ACP 合酶。在固醇合成中，抑制 HMG-CoA 合成酶活性。研究表明，还抑抑制小鼠进食并导致体重急剧下降。
一种抗真菌抗生素，它以等摩尔比结合 β-酮基-ACP 合酶，从而抑制脂肪酸的生物合成。还通过阻断 HMG-CoA 合成酶活性来抑制固醇合成。该化合物的全身性和脑室性活动会减少进食并导致体重减轻。
Other Notes
Loftus, T.M., et al. 2000.Science288, 2379.
Inokashi, J., et al. 1994.Mol.Gen.遗传244, 90.
Schneider, F., et al. 1993.Biochim.Biophys.Acta 1152, 243.
Inokashi, J., et al. 1994.Mol.Gen.遗传244, 90.
Schneider, F., et al. 1993.Biochim.Biophys.Acta 1152, 243.
Packaging
用惰性气体包装
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Verena Baumann et al.
The Journal of cell biology, 223(7) (2024-04-04)
Autophagy serves as a stress response pathway by mediating the degradation of cellular material within lysosomes. In autophagy, this material is encapsulated in double-membrane vesicles termed autophagosomes, which form from precursors referred to as phagophores. Phagophores grow by lipid influx
Byungil Kim et al.
Molecular cell, 78(4), 624-640 (2020-05-08)
The primary interactions between incoming viral RNA genomes and host proteins are crucial to infection and immunity. Until now, the ability to study these events was lacking. We developed viral cross-linking and solid-phase purification (VIR-CLASP) to characterize the earliest interactions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持