Merck
CN
所有图片(1)

文件

220551

Sigma-Aldrich

氯霉素，大包装

Chloramphenicol, CAS 56-75-7, is a synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

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别名:
氯霉素，大包装
经验公式（希尔记法）:
C11H12Cl2N2O5
CAS号:
56-75-7
分子量:
323.13
MDL编号:
MFCD00078159

检测方案

≥97% (by Assay)

形式

crystalline powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

gray to off-white

溶解性

water: 2.5 mg/mL
methanol: 35 mg/mL
ethanol: soluble

运输

ambient

储存温度

10-30°C

InChI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)

InChI key

WIIZWVCIJKGZOK-UHFFFAOYSA-N

相关类别

一般描述

通过与50S核糖体亚基结合来抑制RNA到蛋白质的翻译，从而阻止肽基转移酶反应的合成抑菌抗生素。氯霉素抗性由抗性基因cat编码，其产物氯霉素乙酰转移酶可通过乙酰化使抗生素失活。通常以30-50 µg/ml用于筛选带有氯霉素抗性的大肠杆菌。
通过阻断核糖体上肽基转移酶反应来抑制RNA翻译的合成抑菌抗生素。

生化/生理作用

功效：≥970 µg/mg
首要靶标
RNA的翻译

其他说明

Lech, K., and Brent, R. 1995. in Current Protocols in Mol.Biol. Vol. 1, (Ausubel, F.M., et al., Eds.)John Wiley & Sons, New York.
Lu, J., and Jiang, C. 1993.Biochem.Biophys.Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993.Virol.197, 35.
Holt, J.T. 1992.Ann.N.Y.Acad.Sci.660, 88.
Maniatis, T., et al. 1989.In Molecular Cloning, A Laboratory Manual, Second Edition.Cold Spring Harbor, NY, p. 1.6, A.6.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

CorrosionHealth hazard
GHS05,GHS08

警示用语：

Danger

危险分类

Carc. 2 - Eye Dam. 1 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

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