Merck
CN
所有图片(2)

文件

23-024-M

Sigma-Aldrich

p27 Protein complex, activated, 10 µg

Activated complex of three (3) full length, recombinant human proteins: p27, Cyclin E1, & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.

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别名:
p27 kip1, Cyclin-dependent kinase inhibitor 1B, Kip1
eCl@ss:
32160405
NACRES:
NA.41

生物来源

human

质量水平

100

重组

expressed in baculovirus infected Sf21 cells

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

GenBank® accession no.

BC001971 (p27)

NCBI登记号

NM_001238 (Cyclin E1)
NM_001798

Gene Information

human ... CDK2(1017) , CDKN1B(1027)

一般描述

p27 is an important regulator of cell cycle progression, involved in G1 arrest. It is a potent inhibitor of cyclin E1- and cyclin A-CDK2 complexes and a positive regulator of cyclin D-dependent kinases such as CDK4. The degradation of this protein, which is triggered by its CDK-dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Decreased levels of p27 are found in various epithelial tumours originating from lung, breast, colon, ovary, oesophagus, thyroid and prostate. Defects in the gene encoding p27 (CDKN1B) are the cause of multiple endocrine neoplasia type 4 (MEN4) an inherited cancer of the thyroid.

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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