b-catenin Protein, activated, 10 µg

Ubiquitination Cascade Comoponent: Substrate

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β-catenin is a multifunctional protein; it is a central component of the cadherin cell adhesion complex, regulating the control of cell adhesion and plays an essential role in the Wingless/Wnt signaling pathway that governs cell fate in early embryogenesis. The regulation of β-catenin turnover in the cells is governed by its phosphorylation status which allows the targeting of ubiquitin-dependent proteolysis. Altered levels of protein expression as well as genetic mutations of β-catenin have been implicated in a number of human cancers.

N-terminal GST-tagged, recombinant human Smurf1 full length, expressed in E coli.

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Purified using immobilized metal affinity chromatography.

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