Research area: Apoptosis

N-terminal GST-tagged, recombinant human TRAF6 full length, expressed in E.coli. The p53 protein is a tumor suppressor encoded by TP53 gene located on chromosome 17.

Ubiquitination Cascade Comoponent: Substrate

p53 is expressed in a wide variety of tissues and plays a major role in preventing tumour development. It is involved in cell cycle regulation, functioning as a trans-activator to negatively regulate cell division by controlling a set of genes required for this process. It acts as a tumour suppressor in many tumour types by stimulating either apoptosis or growth arrest, depending on the physiological circumstances and the cell type. Defects in p53 expression have been implicated in several diseases, including choroid plexus papilloma, lung cancer, head/neck squamous cell carcinomas, oesophageal squamous cell carcinoma, Li-Fraumeni syndrome, and hereditary adrenocortical carcinoma.

Purified using immobilized metal affinity chromatography.

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

GenBank is a registered trademark of United States Department of Health and Human Services

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.