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About This Item
经验公式（希尔记法）:
C17H22N2O3 · xHCl
CAS Number:
分子量:
302.37 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
light yellow
溶解性
water: 25 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
Cl.N3(CCOCC3)CCCCNC(=O)c1[o]c2c(c1)cccc2
InChI
1S/C17H22N2O3.ClH/c20-17(16-13-14-5-1-2-6-15(14)22-16)18-7-3-4-8-19-9-11-21-12-10-19;/h1-2,5-6,13H,3-4,7-12H2,(H,18,20);1H
InChI key
PIOACXKZWXHBRB-UHFFFAOYSA-N
一般描述
A selective inhibitor of MMP-13 (IC50 = 10 µM) that does not appear to act by chelating Zn2+. Binds within the entire S1′ pocket of MMP-13, docking with the morpholine ring adjacent to the catalytic zinc atom. Does not inhibit MMP-1, MMP-9, and TACE.
生化/生理作用
Cell permeable: no
Primary Target
MMP-13
MMP-13
Product does not compete with ATP.
Reversible: no
Target IC50: 10 µM against MMP-13
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
其他说明
Chen, J.M., et al. 2000. J. Am. Chem. Soc.122, 9648.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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