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Merck
CN

233183

Sigma-Aldrich

Clodronate disodium Salt

≥97% (titration), bone resorption inhibitor, solid

别名:

Clodronate, Disodium Salt, Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate

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关于此项目

经验公式（希尔记法）:
CH2Cl2Na2O6P2 · 4H2O
CAS Number:
88416-50-6
分子量:
360.92
MDL编号:
MFCD02940846
UNSPSC代码:
12352200
NACRES:
NA.77

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Product Name

Clodronate, Disodium Salt, A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption.

质量水平

100

描述

Merck USA index - 14, 2371

方案

≥97% (titration)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white

溶解性

water: 1 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

[Na+].[Na+].[P](=O)([O-])(O)C([P](=O)([O-])O)(Cl)Cl.O.O.O.O

InChI

1S/CH4Cl2O6P2.2Na.4H2O/c2-1(3,10(4,5)6)11(7,8)9;;;;;;/h(H2,4,5,6)(H2,7,8,9);;;4*1H2/q;2*+1;;;;/p-2

InChI key

XWHPUCFOTRBMGS-UHFFFAOYSA-L

相关类别

一般描述

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
A non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC50 = 100 nM).

生化/生理作用

Cell permeable: no
Primary Target
Osteoclast-mediated bone resorption
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells

其他说明

Lehenkari, P.P., et al. 2002. Mol. Pharmacol.61, 1255.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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