Coagulation Factor α-XIIa, Human Plasma

Native coagulation factor α-XIIa from human plasma prepared from homogeneous Factor XII using dextran sulfate. Dextran sulfate is removed after activation. α-XIIa is a serine protease responsible for activation of Factor XI to Factor XIa. Factor XIIa and prekallikrein are thought to be involved in a reciprocal activation mechanism whereby Factor XIIa activates prekallikrein to kallikrein, which in turn converts Factor XII to Factor XIIa.

Please refer to vial label for lot-specific concentration.

In 150 mM NaCl, 4 mM sodium acetate buffer, pH 5.3.

Following initial thaw, aliquot and freeze (-70°C).

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma

homogeneous by SDS-PAGE

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)