Name: Colchicine
Brand: MM

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About This Item

经验公式（希尔记法）:

C₂₂H₂₅NO₆

CAS Number:

64-86-8

分子量:

399.44

MDL编号:

MFCD00078484

UNSPSC代码:

12352200

NACRES:

NA.77

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Product Name

Colchicine, Colchicum autumnale, Colchicine, Colchicum autumnale, CAS 64-86-8, is an inhibitor of mitosis that disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 and cerebellar granule cells.

质量水平

100

描述

Merck USA index - 14, 2471

方案

≥94% (HPLC)

表单

powder

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
protect from light

颜色

yellow to off-white

溶解性

ethanol: 10 mg/mL
water: soluble

运输

ambient

储存温度

10-30°C

SMILES字符串

N([C@H]1CCc2c(c(c(c(c2)OC)OC)OC)c3c1c[c](c(cc3)OC)=O)C(=O)C

InChI

1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChI key

IAKHMKGGTNLKSZ-INIZCTEOSA-N

一般描述

Inhibitor of mitosis that is useful in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 cells and in cerebellar granule cells.

Major alkaloid of Colchicum autumnale. Inhibitor of mitosis used in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in pheochromocytoma (PC12) cells and in cerebellar granule cells.

生化/生理作用

Cell permeable: no

Primary Target
Inhibitor of mitosis

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

其他说明

Bonfoco, E., et al. 1995. Exp. Cell Res.218, 189.
Lindenboim, L., et al. 1995. J. Neurochem.64, 1054.
Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res.16, 929.
Santell, L. 1992. Exp. Cell Res. 201, 358.
Salmon, E.D., et al. 1984. J. Cell Biol.99, 1066.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

GHS06,GHS08

警示用语：

Danger

危险声明

H300,H340

预防措施声明

P202 - P264 - P280 - P301 + P310 - P405 - P501

危险分类

Acute Tox. 2 Oral - Muta. 1B

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)