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Merck
CN

234610

Sigma-Aldrich

Congo Red, High Purity

An amyloidophylic dye that specifically stains stacked β sheet aggregates.

别名:

Congo Red, High Purity, 3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na

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关于此项目

经验公式（希尔记法）:
C32H22N6O6S2 · 2Na
化学文摘社编号:
573-58-0
分子量:
696.66
MDL编号:
MFCD00004028
UNSPSC代码:
12171500
NACRES:
NA.25

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质量水平

100

描述

Merck USA index - 14, 2498

方案

≥75% dye basis

表单

crystalline solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

rust

溶解性

water: 10 mg/mL
ethanol: soluble

运输

ambient

储存温度

15-25°C

SMILES字符串

[Na+].[Na+].[S](=O)(=O)([O-])c1c2c(c(c(c1)N=Nc3ccc(cc3)c4ccc(cc4)N=Nc5c(c6c(c(c5)[S](=O)(=O)[O-])cccc6)N)N)cccc2

InChI

1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2

InChI key

IQFVPQOLBLOTPF-UHFFFAOYSA-L

一般描述

An amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA.

生化/生理作用

Cell permeable: no
Primary Target
An amyloidophylic dye that specifically stains stacked β sheet aggregates
Product does not compete with ATP.
Reversible: no

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).

其他说明

Altschuler, S.E., et al. 2012. Biochemistrin press.
Khurana, R., et al. 2001. J. Biol. Chem.276, 22715.
Fezoui, Y., et al. 2000. Amyloid7, 166.
Fezoui, Y., et al. 2000. Nat. Struct. Biol.7, 1095.
Kramport, M., et al. 2000. Chem. Biol.7, 855.
Kuner, P., et al. 2000. J. Biol. Chem.275, 1673.
Caspi, S., et al. 1998. J. Biol. Chem.273, 3484.
Caughey, B., and Race, A.E. 1992. J. Neurochem.59, 768.
Taylor, D.L., et al. 1974. J. Histochem. Cytochem.22, 1105.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H350,H361d

危险分类

Carc. 1B - Repr. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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