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234610

Congo Red, High Purity

Name: Congo Red, High Purity
Brand: MM

An amyloidophylic dye that specifically stains stacked β sheet aggregates.

别名:

Congo Red, High Purity, 3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na

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关于此项目

经验公式（希尔记法）:

C₃₂H₂₂N₆O₆S₂ · 2Na

化学文摘社编号:

573-58-0

分子量:

696.66

UNSPSC Code:

12171500

NACRES:

NA.25

MDL number:

MFCD00004028

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属性

Quality Segment

100

description

Merck USA index - 14, 2498

assay

≥75% dye basis

form

crystalline solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

rust

solubility

water: 10 mg/mL, ethanol: soluble

shipped in

ambient

storage temp.

15-25°C

SMILES string

[Na+].[Na+].[S](=O)(=O)([O-])c1c2c(c(c(c1)N=Nc3ccc(cc3)c4ccc(cc4)N=Nc5c(c6c(c(c5)[S](=O)(=O)[O-])cccc6)N)N)cccc2

InChI

1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2

InChI key

IQFVPQOLBLOTPF-UHFFFAOYSA-L

说明

General description

An amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA.

Biochem/physiol Actions

Cell permeable: no

Primary Target
An amyloidophylic dye that specifically stains stacked β sheet aggregates

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).

Other Notes

Altschuler, S.E., et al. 2012. Biochemistrin press.
Khurana, R., et al. 2001. J. Biol. Chem.276, 22715.
Fezoui, Y., et al. 2000. Amyloid7, 166.
Fezoui, Y., et al. 2000. Nat. Struct. Biol.7, 1095.
Kramport, M., et al. 2000. Chem. Biol.7, 855.
Kuner, P., et al. 2000. J. Biol. Chem.275, 1673.
Caspi, S., et al. 1998. J. Biol. Chem.273, 3484.
Caughey, B., and Race, A.E. 1992. J. Neurochem.59, 768.
Taylor, D.L., et al. 1974. J. Histochem. Cytochem.22, 1105.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

pictograms

GHS08

signalword

Danger

hcodes

H350,H361d

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 1B - Repr. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

历史批次信息供参考:

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