236020
依托莫西
≥98% (HPLC), solid, CPT-1 inhibitor
别名:
依托莫西, R(+)-2-[6-(4-氯苯氧基）己基]-环氧乙烷-2-羧酸钠盐水合物
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关于此项目
经验公式（希尔记法）:
C15H18ClO4 · Na
化学文摘社编号:
分子量:
320.74
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
产品名称
依托莫西, A cell-permeable, irreversible, and stereospecific compound that is shown to inhibit carnitine palmitoyltransferase (CPT)-1 and DGAT activity in the mitochondria of rat heart H9c2 myoblastic cells.
Quality Level
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL (or water)
shipped in
wet ice
storage temp.
2-8°C
SMILES string
[Na+].Clc1ccc(cc1)OCCCCCC[C@]2(OC2)C(=O)[O-]
InChI
1S/C15H19ClO4.Na/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;/h5-8H,1-4,9-11H2,(H,17,18);/q;+1/p-1/t15-;/m1./s1
InChI key
RPACBEVZENYWOL-XFULWGLBSA-M
General description
Etomoxir (ETO), an irreversible inhibitor of carnitine palmitoyltransferase I (CPT1), primarily impacts fatty acid oxidation. It is an epoxide-based medium-chain fatty acid used to study the biological effects of mitochondrial fatty acid β-oxidation. ETO shifts energy metabolism from fatty acids to glucose oxidation. Its mechanism of action involves reducing the transport of non-esterified fatty acids (NEFA) into the mitochondrial matrix, which subsequently reduces the substrate available for β-oxidation.
Application
Etomoxir has been used in:
- the evaluation of long-chain fatty acid respiration in neonatal mouse cardiomyocytes using SeaHorse instrument
- cell stimulation experiments to study its effects on fatty acid oxidation in metabolic syndrome-associated synoviocytes
- Seahorse assays to assess fatty acid oxidation in cultured cells by inhibiting carnitine palmitoyltransferase I (CPT1)
Other Notes
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有毒（F）
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Maria A Ahonen et al.
Molecular medicine (Cambridge, Mass.), 28(1), 68-68 (2022-06-18)
Thyroid hormone responsive protein (THRSP) is a lipogenic nuclear protein that is highly expressed in murine adipose tissue, but its role in humans remains unknown. We characterized the insulin regulation of THRSP in vivo in human adipose tissue biopsies and
Aude Angelini et al.
STAR protocols, 3(2), 101392-101392 (2022-05-24)
Metabolic switches play a critical role in the pathophysiology of cardiac diseases, including heart failure. Here, we describe an assay for long-chain fatty acid oxidation in neonatal mouse cardiomyocytes by using a SeaHorse Flux Analyzer (Agilent). This protocol is a
Kristina Seiler et al.
Cell death & disease, 13(5), 448-448 (2022-05-11)
The family of hexokinases (HKs) catalyzes the first step of glycolysis, the ATP-dependent phosphorylation of glucose to glucose-6-phosphate. While HK1 and HK2 are ubiquitously expressed, the less well-studied HK3 is primarily expressed in hematopoietic cells and tissues and is highly
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 236020-5MG | 04055977217162 |