238900
4-Cyano-3-methylisoquinoline
A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC50 = 30 nM).
别名:
4-Cyano-3-methylisoquinoline, PKA Inhibitor XI
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关于此项目
经验公式（希尔记法）:
C11H8N2
化学文摘社编号:
分子量:
168.19
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
n1cc2c(c(c1C)C#N)cccc2
InChI
1S/C11H8N2/c1-8-11(6-12)10-5-3-2-4-9(10)7-13-8/h2-5,7H,1H3
InChI key
SZWLGBJCLZDZBY-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 50 mg/mL
shipped in
ambient
Quality Level
General description
A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase.
A potent, cell-permeable, specific inhibitor of protein kinase A (PKA; IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase (Pase).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKA
PKA
Product competes with ATP.
Reversible: yes
Target IC50: 30 nM against protein kinase A
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Lu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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