239806
Cyclopamine
from Veratrum californicum, ≥97% (NMR), Shh pathway inhibitor, liquid
别名:
InSolution环巴胺，来源于加州藜芦, EtOH中Shh信号传导拮抗剂I
产品名称
环巴胺，V，来源于加州藜芦, InSolution, ≥97%, controls the biological activity of Sonic Hedgehog signaling pathway
质量水平
方案
≥97% (NMR)
表单
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
运输
ambient
储存温度
−70°C
SMILES字符串
OC(C1)CCC2(C)C1=CCC3C2CC4=C(C)[C@@]5(O[C@@H](C[C@H](C)CN6)[C@@H]6[C@H]5C)CCC34
一般描述
一种具有细胞渗透性的甾体生物碱和胆固醇模拟物，同时具有致畸性和抗肿瘤活性。它通过与G蛋白偶联受体的远亲Smo（smoothened）直接相互作用来破坏胆固醇的生物合成，并特异性拮抗shh（音猬因子）信号传导通路。研究shh信号传导参与各种肿瘤发展的有价值的工具。番茄碱可用作阴性对照品。另提供该化合物的固体形式（目录号239803）。
包装
用惰性气体包装
外形
加州藜芦来源环巴胺固体（货号239803）的乙醇溶液，浓度10 mM（5 mg/1.22 mL）。
制备说明
初次解冻后，分装冻存（-70°C）。
其他说明
Berman, D.M., et al. 2003.Nature,425, 846.
Thayer, S.P., et al. 2003.Nature,425, 851.
Watkins, D.N., et al. 2003.Nature422, 313.
Chen, J.K., et al. 2002.Proc.Natl.Acad.Sci. USA99, 14071.
Berman, D.M., et al. 2002.Science297, 1559.
Taipale, J., et al. 2000.Nature406, 1005.
Kim, S.K., and Melton, D.A.1998.Proc.Natl.Acad.Sci. USA95, 13036.
Cooper, M.K., et al. 1998.Science280, 1603.
Incardona, J.P., et al. 1998.Development125, 3553.
Thayer, S.P., et al. 2003.Nature,425, 851.
Watkins, D.N., et al. 2003.Nature422, 313.
Chen, J.K., et al. 2002.Proc.Natl.Acad.Sci. USA99, 14071.
Berman, D.M., et al. 2002.Science297, 1559.
Taipale, J., et al. 2000.Nature406, 1005.
Kim, S.K., and Melton, D.A.1998.Proc.Natl.Acad.Sci. USA95, 13036.
Cooper, M.K., et al. 1998.Science280, 1603.
Incardona, J.P., et al. 1998.Development125, 3553.
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法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：易燃（J）
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2 - Repr. 1B
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
53.6 °F - closed cup - Information refers to the main ingredient.
闪点(°C)
12 °C - closed cup - Information refers to the main ingredient.
法规信息
危险化学品
此项目有
Xin Chen et al.
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The risk of pancreatic cancer is higher among people who are cigarette smokers than among non-smokers; however, the action mechanisms of cigarette metabolites are not yet fully understood. In this study, we investigated the effect of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in cigarette
Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome.
Moyer, et al.
Disease models & mechanisms, 16 (2023)
Elena A May et al.
The Journal of cell biology, 220(5) (2021-04-16)
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