239806
Cyclopamine
from Veratrum californicum, ≥97% (NMR), Shh pathway inhibitor, liquid
别名:
InSolution环巴胺，来源于加州藜芦, EtOH中Shh信号传导拮抗剂I
产品名称
环巴胺，V，来源于加州藜芦, InSolution, ≥97%, controls the biological activity of Sonic Hedgehog signaling pathway
SMILES string
OC(C1)CCC2(C)C1=CCC3C2CC4=C(C)[C@@]5(O[C@@H](C[C@H](C)CN6)[C@@H]6[C@H]5C)CCC34
assay
≥97% (NMR)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
shipped in
ambient
storage temp.
−70°C
Quality Level
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：易燃（J）
General description
一种具有细胞渗透性的甾体生物碱和胆固醇模拟物，同时具有致畸性和抗肿瘤活性。它通过与G蛋白偶联受体的远亲Smo（smoothened）直接相互作用来破坏胆固醇的生物合成，并特异性拮抗shh（音猬因子）信号传导通路。研究shh信号传导参与各种肿瘤发展的有价值的工具。番茄碱可用作阴性对照品。另提供该化合物的固体形式（目录号239803）。
Other Notes
Berman, D.M., et al. 2003.Nature,425, 846.
Thayer, S.P., et al. 2003.Nature,425, 851.
Watkins, D.N., et al. 2003.Nature422, 313.
Chen, J.K., et al. 2002.Proc.Natl.Acad.Sci. USA99, 14071.
Berman, D.M., et al. 2002.Science297, 1559.
Taipale, J., et al. 2000.Nature406, 1005.
Kim, S.K., and Melton, D.A.1998.Proc.Natl.Acad.Sci. USA95, 13036.
Cooper, M.K., et al. 1998.Science280, 1603.
Incardona, J.P., et al. 1998.Development125, 3553.
Thayer, S.P., et al. 2003.Nature,425, 851.
Watkins, D.N., et al. 2003.Nature422, 313.
Chen, J.K., et al. 2002.Proc.Natl.Acad.Sci. USA99, 14071.
Berman, D.M., et al. 2002.Science297, 1559.
Taipale, J., et al. 2000.Nature406, 1005.
Kim, S.K., and Melton, D.A.1998.Proc.Natl.Acad.Sci. USA95, 13036.
Cooper, M.K., et al. 1998.Science280, 1603.
Incardona, J.P., et al. 1998.Development125, 3553.
由于该运输中有害物质的性质，您的订单可能需要支付额外的运输费用。某些尺寸的产品可免除其他有害材料的运输费用。请与您当地的销售办事处联系，以获取有关这些费用的更多信息。
Packaging
用惰性气体包装
Physical form
加州藜芦来源环巴胺固体（货号239803）的乙醇溶液，浓度10 mM（5 mg/1.22 mL）。
Preparation Note
初次解冻后，分装冻存（-70°C）。
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - Repr. 1B
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
53.6 °F - closed cup - Information refers to the main ingredient.
flash_point_c
12 °C - closed cup - Information refers to the main ingredient.
法规信息
危险化学品
此项目有
Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome.
Moyer, et al.
Disease models & mechanisms, 16 (2023)
Elena A May et al.
The Journal of cell biology, 220(5) (2021-04-16)
The primary cilium is a signaling compartment that interprets Hedgehog signals through changes of its protein, lipid, and second messenger compositions. Here, we combine proximity labeling of cilia with quantitative mass spectrometry to unbiasedly profile the time-dependent alterations of the
Xin Chen et al.
iScience, 25(1), 103647-103647 (2022-01-15)
The risk of pancreatic cancer is higher among people who are cigarette smokers than among non-smokers; however, the action mechanisms of cigarette metabolites are not yet fully understood. In this study, we investigated the effect of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in cigarette
Justine D Manos et al.
iScience, 25(1), 103658-103658 (2022-01-25)
Tau pathobiology has emerged as a key component underlying Alzheimer's disease (AD) progression; however, human neuronal in vitro models have struggled to recapitulate tau phenomena observed in vivo. Here, we aimed to define the minimal requirements to achieve endogenous tau aggregation in
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