239807
环巴胺-KAAD
≥70% (sum of two isomers, HPLC), liquid, Hedgehog signaling inhibitor, Calbiochem®
别名:
3-酮-N-（氨基乙基-氨基己酰基-二氢肉桂酰基）环巴胺, InSolution 环巴胺-KAAD
产品名称
环巴胺-KAAD, InSolution, ≥70%, inhibits Hedgehog (Hh) signaling
form
liquid
assay
≥70% (sum of two isomers, HPLC)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
shipped in
dry ice
storage temp.
−70°C
Quality Level
General description
Biochem/physiol Actions
主要靶标
SmoA1
SmoA1
细胞可渗透性：是
Packaging
用惰性气体包装
Physical form
1 mM(50 µg/72 µL)的环巴胺-KAAD（货号239804）的DMSO溶液。
Preparation Note
初次解冻后，分装冻存（-70°C）。分装后在-70°C下可稳定保存6个月。
Other Notes
Siegelin, M.D. et al. 2009.Neurobiol.Dis.34, 259.
Watkins, D.N., et al. 2003.Nature422, 313.
Berman, D.M., et al. 2002.Science297, 1559.
Chen, J.K., et al. 2002.Proc.Natl.Acad.Sci. USA99, 14071.
Chen, J.K., et al. 2002.Genes Dev.16, 2743.
Frank-Kamenetsky, M., et al. 2002.J. Biol.1, 10.
Taipale, J., et al. 2000.Nature406, 1005.
Watkins, D.N., et al. 2003.Nature422, 313.
Berman, D.M., et al. 2002.Science297, 1559.
Chen, J.K., et al. 2002.Proc.Natl.Acad.Sci. USA99, 14071.
Chen, J.K., et al. 2002.Genes Dev.16, 2743.
Frank-Kamenetsky, M., et al. 2002.J. Biol.1, 10.
Taipale, J., et al. 2000.Nature406, 1005.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
wgk
WGK 1
存储类别
10 - Combustible liquids
flash_point_f
188.6 °F - closed cup - (refers to pure substance)
flash_point_c
87 °C - closed cup - (refers to pure substance)
Betty R Lawton et al.
Endocrinology, 161(10) (2020-08-19)
Differentiation of pluripotent stem cells into functional parathyroid-like cells would accelerate development of important therapeutic options for subjects with parathyroid-related disorders, from the design and screening of novel pharmaceutical agents to the development of durable cellular therapies. We have established
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