239835
环孢菌素 A，来源于多孔木霉
Cyclosporin A, CAS 59865-13-3, is an immunosuppressant that induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. Induces cardiomyocytes formation from ESCs.
别名:
环孢菌素 A，来源于多孔木霉
InChI
1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+
InChI key
PMATZTZNYRCHOR-IMVLJIQESA-N
assay
≥97% dry basis
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to off-white
solubility
DMSO: 25 mg/mL, chloroform: soluble, ethanol: soluble, methanol: soluble
shipped in
ambient
Quality Level
General description
具有免疫抑制属性的环状寡肽。诱导大鼠胸腺细胞和鼠B细胞淋巴瘤细胞系WEHI-231的凋亡。但是，它可以在BLB细胞系中阻止抗-IgM和离子霉素诱导的细胞凋亡。环孢菌素A与亲环蛋白的复合物可以纳摩尔的亲和力对蛋白磷酸酶2B进行抑制。抑制由白介素-1α、脂多糖和TNF-α诱导的一氧化氮合成。从胚胎干细胞诱导形成心肌细胞。
材料是具有免疫抑制活性的一种非极性环状寡肽。似乎是通过与细胞内蛋白亲环蛋白相互作用而起作用的。亲环蛋白-环孢菌素A复合物是钙调神经磷酸酶（蛋白磷酸酶2B，PP2B）蛋白磷酸酶活性的一种有效抑制剂。诱导大鼠胸腺细胞和鼠B细胞淋巴瘤细胞系WEHI-231的凋亡；但是，它可以在BLB细胞系中阻止抗-IgM和离子霉素诱导的细胞凋亡。抑制由白介素1α、脂多糖和TNFα诱导的一氧化氮合成。从胚胎干细胞诱导形成心肌细胞。
Biochem/physiol Actions
产物不与ATP竞争。
可逆：否
细胞渗透性：否
首要靶标
由白介素-1-诱导的NOSα
由白介素-1-诱导的NOSα
Preparation Note
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Other Notes
Yan, P., et al. 2008.Biochem.Biophys.Res. Commun.in press.
Hattori, Y., and Naranishi, N. 1995.Cell Immunol.165, 7.
Marumo, T., et al. 1995.Hypertension25, 764.
Crabtree, G.R., and Clipstone, N.A.1994.Annu.Rev. Biochem.63, 1045.
Gottschalk, A.R., et al. 1994.Proc.Natl.Acad.Sci. USA91, 7350.
Montague, J.W., et al. 1994.J. Biol. Chem.269, 18877.
Fast, D.J., et al. 1993.J.Interferon Res. 13, 235.
Liu, J. 1993.Trends Pharmacol.Sci. 14, 182.
Fruman, D.A., et al. 1992.Proc.Natl.Acad.Sci. USA89, 3686.
Hattori, Y., and Naranishi, N. 1995.Cell Immunol.165, 7.
Marumo, T., et al. 1995.Hypertension25, 764.
Crabtree, G.R., and Clipstone, N.A.1994.Annu.Rev. Biochem.63, 1045.
Gottschalk, A.R., et al. 1994.Proc.Natl.Acad.Sci. USA91, 7350.
Montague, J.W., et al. 1994.J. Biol. Chem.269, 18877.
Fast, D.J., et al. 1993.J.Interferon Res. 13, 235.
Liu, J. 1993.Trends Pharmacol.Sci. 14, 182.
Fruman, D.A., et al. 1992.Proc.Natl.Acad.Sci. USA89, 3686.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：致癌/致畸（D）
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Zoë Steier et al.
Nature immunology, 24(9), 1579-1590 (2023-08-15)
The development of CD4+ T cells and CD8+ T cells in the thymus is critical to adaptive immunity and is widely studied as a model of lineage commitment. Recognition of self-peptide major histocompatibility complex (MHC) class I or II by
Sabrina Giampaolo et al.
iScience, 26(3), 106234-106234 (2023-03-18)
In thymus, the ablation of T cell receptor (TCR)-activated transcription factor NFATc1 or its inducible isoforms during the double-negative (DN) stages of thymocyte development leads to a marked increase in γδ thymocytes whereas the development of αβ thymocytes remains mostly unaffected.
Yunqing Li et al.
Pharmaceutics, 13(8) (2021-08-29)
Hypoxia is a complex microenvironmental condition known to regulate choline kinase α (CHKA) activity and choline transport through transcription factor hypoxia-inducible factor-1α (HIF-1α) and, therefore, may confound the uptake of choline radiotracer [18F]fluoromethyl-[1,2-2H4]-choline ([18F]-D4-FCH). The aim of this study was
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Neurology international, 16(3), 653-662 (2024-06-26)
The tau protein is a microtubule-associated protein that promotes microtubule stabilization. The phosphorylation of the tau protein has been linked to its dissociation from microtubules. Here, we examined the relationship between neuronal depolarization activity and tau protein phosphorylation by employing
Magda N Hernández Vásquez et al.
The EMBO journal, 40(12), e107192-e107192 (2021-05-03)
The lymphatic system is composed of a hierarchical network of fluid absorbing lymphatic capillaries and transporting collecting vessels. Despite distinct functions and morphologies, molecular mechanisms that regulate the identity of the different vessel types are poorly understood. Through transcriptional analysis
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