跳转至内容
Merck
CN

250233

Cytochalasin B

from Helminthosporium dematioideum, ≥98% (HPLC), solid, cell-permeable fungal toxin, Calbiochem®

别名:

细胞松弛素B，来源于长蠕孢菌

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C29H37NO5
化学文摘社编号:
14930-96-2
分子量:
479.61
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00077704

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

细胞松弛素B，来源于长蠕孢菌, Cell-permeable fungal toxin.

SMILES string

N1[C@H]([C@H]3[C@@]4(OC(=O)\C=C\[C@@H](CCC[C@H](C\C=C\[C@H]4[C@@H](C(=C)[C@H]3C)O)C)O)C1=O)Cc2ccccc2

InChI

1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1

InChI key

GBOGMAARMMDZGR-TYHYBEHESA-N

description

Merck USA index - 14, 2790

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

methanol: 20 mg/mL
DMSO: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

相关类别

Biochem/physiol Actions

主要目的
阻断收缩性微丝的形成
产品不与ATP竞争。
可逆：否
细胞渗透性：是

Disclaimer

劣质DMSO会导致产品降解，因此建议选用高质量的DMSO。
毒性：&

General description

细胞可透过性真菌毒素。通过阻止收缩性微丝的形成来抑制细胞质分裂。抑制细胞运动并诱导核挤压。通过阻止聚合物快速生长端的单体添加来缩短肌动蛋白丝。抑制葡萄糖转运和血小板聚集。阻断腺苷诱导的凋亡小体形成，而不影响白血病HL-60细胞内源性ADP核糖基化的激活。

Other Notes

Tanaka, Y., et al. 1994.Exp.Cell Res. 213, 242.
Theodoropoulos, P.A., et al. 1994.生物化学。Pharmacol.47, 1875.
Benya, P.D., and Padilla, S.R.1993.Exp.Cell Res. 204, 268.
Cairns, M.T., et al. 1991.J. Biol. Chem.266, 8176.
Nowak, D. 1990.Biomed.Biochim.Acta49, 353.
Wang, F., et al. 1990.Biochem.Biophys.Res. Commun.171, 543.
Edwards, S.W., and Lloyd, D. 1988.FEBS Lett.227, 39.
由于该运输中有害物质的性质，您的订单可能需要支付额外的运输费用。某些尺寸的产品可免除其他有害材料的运输费用。请与您当地的销售办事处联系，以获取有关这些费用的更多信息。

Preparation Note

复溶后，储存在冰箱中（4°C）。储备溶液在4°C下可稳定保存3个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

法规信息

涉药品监管产品
此项目有

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Lin Meng et al.
Frontiers in cell and developmental biology, 9, 746237-746237 (2021-11-13)
[Ca2+]i is essential for mammalian oocyte maturation and early embryonic development, as those processes are Ca2+ dependent. In the present study, we investigated the effect of [Ca2+]i on in vitro maturation and reprogramming of oocytes in a lower calcium model
Naomi Watanabe et al.
Scientific reports, 13(1), 11175-11175 (2023-07-11)
Wild-derived mouse strains have been extensively used in biomedical research because of the high level of inter-strain polymorphisms and phenotypic variations. However, they often show poor reproductive performance and are difficult to maintain by conventional in vitro fertilization and embryo
Shuyue Qi et al.
PLoS biology, 20(8), e3001741-e3001741 (2022-08-17)
Mitochondrial DNA (mtDNA) mutations are often associated with incurable diseases and lead to detectable pathogenic variants in 1 out of 200 babies. Uncoupling of the inheritance of mtDNA and the nuclear genome by spindle transfer (ST) can potentially prevent the
Michael J Burgum et al.
Mutagenesis, 39(3), 205-217 (2024-03-19)
The current Organisation for Economic Co-Operation and Development test guideline number 487 (OECD TG No. 487) provides instruction on how to conduct the in vitro micronucleus assay. This assay is one of the gold standard approaches for measuring the mutagenicity
Jing Chen et al.
Scientific reports, 11(1), 16798-16798 (2021-08-20)
Tunneling nanotube (TNT), a dynamic cell-cell contact, is dependent on actin polymerization. TNTs are efficient in transporting ions, proteins and organelles intercellularly, which are important mechanisms in physiological and pathological processes. Reported studies on the existence and function of TNTs
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持