250233
Cytochalasin B
from Helminthosporium dematioideum, ≥98% (HPLC), solid, cell-permeable fungal toxin, Calbiochem®
别名:
细胞松弛素B，来源于长蠕孢菌
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关于此项目
经验公式（希尔记法）:
C29H37NO5
化学文摘社编号:
分子量:
479.61
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
产品名称
细胞松弛素B，来源于长蠕孢菌, Cell-permeable fungal toxin.
Quality Level
description
Merck USA index - 14, 2790
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
methanol: 20 mg/mL, DMSO: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
N1[C@H]([C@H]3[C@@]4(OC(=O)\C=C\[C@@H](CCC[C@H](C\C=C\[C@H]4[C@@H](C(=C)[C@H]3C)O)C)O)C1=O)Cc2ccccc2
InChI
1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChI key
GBOGMAARMMDZGR-TYHYBEHESA-N
General description
细胞可透过性真菌毒素。通过阻止收缩性微丝的形成来抑制细胞质分裂。抑制细胞运动并诱导核挤压。通过阻止聚合物快速生长端的单体添加来缩短肌动蛋白丝。抑制葡萄糖转运和血小板聚集。阻断腺苷诱导的凋亡小体形成，而不影响白血病HL-60细胞内源性ADP核糖基化的激活。
Biochem/physiol Actions
主要目的
阻断收缩性微丝的形成
阻断收缩性微丝的形成
产品不与ATP竞争。
可逆：否
细胞渗透性：是
Preparation Note
复溶后，储存在冰箱中（4°C）。储备溶液在4°C下可稳定保存3个月。
Other Notes
Tanaka, Y., et al. 1994.Exp.Cell Res. 213, 242.
Theodoropoulos, P.A., et al. 1994.生物化学。Pharmacol.47, 1875.
Benya, P.D., and Padilla, S.R.1993.Exp.Cell Res. 204, 268.
Cairns, M.T., et al. 1991.J. Biol. Chem.266, 8176.
Nowak, D. 1990.Biomed.Biochim.Acta49, 353.
Wang, F., et al. 1990.Biochem.Biophys.Res. Commun.171, 543.
Edwards, S.W., and Lloyd, D. 1988.FEBS Lett.227, 39.
Theodoropoulos, P.A., et al. 1994.生物化学。Pharmacol.47, 1875.
Benya, P.D., and Padilla, S.R.1993.Exp.Cell Res. 204, 268.
Cairns, M.T., et al. 1991.J. Biol. Chem.266, 8176.
Nowak, D. 1990.Biomed.Biochim.Acta49, 353.
Wang, F., et al. 1990.Biochem.Biophys.Res. Commun.171, 543.
Edwards, S.W., and Lloyd, D. 1988.FEBS Lett.227, 39.
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
劣质DMSO会导致产品降解，因此建议选用高质量的DMSO。
毒性：&
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 250233-5MG | 04055977199147 |