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Merck
CN

251400

Sigma-Aldrich

D609 Potassium Salt

≥98% (HPLC), Phosphatidylcholine-specific phospholipase C inhibitor, powder

别名:

D609, Potassium Salt, Tricyclodecan-9-yl-xanthogenate, K

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关于此项目

经验公式(希尔记法):
C11H15OS2 · K
化学文摘社编号:
分子量:
266.46
MDL编号:
UNSPSC代码:
41106500
NACRES:
NA.77
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产品名称

D609, Potassium Salt, Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 µM).

质量水平

方案

≥98% (HPLC)

表单

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

off-white

溶解性

DMSO: 25 mg/mL
water: 25 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

[K].SC(=S)OC1C2C3C(C(C2)C1)CCC3

InChI

1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);

InChI key

YFUFHKMDCZBHMY-UHFFFAOYSA-N

一般描述

Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) (Bacillus cereus, Ki = 5-10 µM). Does not inhibit (up to 50 µM) phosphatidylinositol-specific phospholipase C, phospholipase A2, and phospholipase D. Inhibitor of the sphingomyelinase activity. Also inhibits angiogenesis by preventing the synthesis of basement membrane (BM).

生化/生理作用

Cell permeable: no
Primary Target
pc-specificphopholipase c
Product does not compete with ATP.
Reversible: no
Target Ki: 5-10 µM against phosphatidylcholine (PC)-specific phospholipase C

制备说明

Material is very labile once in solution (1.5 day half-life in tissue culture medium).
tissue culture media should be at neutral pH, since product is active only at or slightly below pH 7.0. The compound is inactive at pH 7.4 and above, and it is hydrolyzed below pH 6.0. HEPES buffer should not be used as it renders D609 toxic.

其他说明

Monick, M.M., et al. 1999. J. Immunol. 162, 3005.
Lozanski, G., et al. 1997. Biochem. J.328, 271.
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses8, 245.
Schutze, S., et al. 1992. Cell71, 765.
Sauer, G., et al. 1990. Cancer Lett.53, 97.
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun.162, 198.
Amtmann, E., et al. 1987. Biochem. Pharmacol.36, 1545.
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA81, 3263.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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