251400
D609 Potassium Salt
≥98% (HPLC), Phosphatidylcholine-specific phospholipase C inhibitor, powder
别名:
D609, Potassium Salt, Tricyclodecan-9-yl-xanthogenate, K
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关于此项目
经验公式（希尔记法）:
C11H15OS2 · K
化学文摘社编号:
分子量:
266.46
UNSPSC Code:
41106500
NACRES:
NA.77
MDL number:
产品名称
D609, Potassium Salt, Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 µM).
SMILES string
[K].SC(=S)OC1C2C3C(C(C2)C1)CCC3
InChI
1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);
InChI key
YFUFHKMDCZBHMY-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
off-white
solubility
DMSO: 25 mg/mL, water: 25 mg/mL
shipped in
ambient
Quality Level
General description
Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) (Bacillus cereus, Ki = 5-10 µM). Does not inhibit (up to 50 µM) phosphatidylinositol-specific phospholipase C, phospholipase A2, and phospholipase D. Inhibitor of the sphingomyelinase activity. Also inhibits angiogenesis by preventing the synthesis of basement membrane (BM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
pc-specificphopholipase c
pc-specificphopholipase c
Product does not compete with ATP.
Reversible: no
Target Ki: 5-10 µM against phosphatidylcholine (PC)-specific phospholipase C
Preparation Note
Material is very labile once in solution (1.5 day half-life in tissue culture medium).
tissue culture media should be at neutral pH, since product is active only at or slightly below pH 7.0. The compound is inactive at pH 7.4 and above, and it is hydrolyzed below pH 6.0. HEPES buffer should not be used as it renders D609 toxic.
Other Notes
Monick, M.M., et al. 1999. J. Immunol. 162, 3005.
Lozanski, G., et al. 1997. Biochem. J.328, 271.
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses8, 245.
Schutze, S., et al. 1992. Cell71, 765.
Sauer, G., et al. 1990. Cancer Lett.53, 97.
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun.162, 198.
Amtmann, E., et al. 1987. Biochem. Pharmacol.36, 1545.
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA81, 3263.
Lozanski, G., et al. 1997. Biochem. J.328, 271.
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses8, 245.
Schutze, S., et al. 1992. Cell71, 765.
Sauer, G., et al. 1990. Cancer Lett.53, 97.
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun.162, 198.
Amtmann, E., et al. 1987. Biochem. Pharmacol.36, 1545.
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA81, 3263.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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